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Andreas Ruppert
Publications - 3
Citations - 1193
Andreas Ruppert is an academic researcher. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 3, co-authored 3 publications receiving 1146 citations.
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Journal ArticleDOI
A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci
Sreekumar G. Pillai,Dongliang Ge,Guohua Zhu,Xiangyang Kong,Kevin V. Shianna,Anna C. Need,Sheng Feng,Craig P. Hersh,Per Bakke,Amund Gulsvik,Andreas Ruppert,Karin C. Lødrup Carlsen,Allen D. Roses,Allen D. Roses,Wayne Anderson,Stephen I. Rennard,David A. Lomas,Edwin K. Silverman,David Goldstein +18 more
TL;DR: A genome-wide association study in a homogenous case-control cohort from Bergen, Norway and evaluated the top 100 single nucleotide polymorphisms (SNPs) in the family-based International COPD Genetics Network found two SNPs at the α-nicotinic acetylcholine receptor (CHRNA 3/5) locus showed unambiguous replication and were significantly associated with lung function in both the ICGN and Boston Early-Onset COPD populations.
Journal ArticleDOI
A genome-wide investigation of SNPs and CNVs in schizophrenia
Anna C. Need,Dongliang Ge,Michael E. Weale,Jessica M. Maia,Sheng Feng,Erin L. Heinzen,Kevin V. Shianna,Woohyun Yoon,Dalia Kasperavičiūtė,Massimo Gennarelli,Warren J. Strittmatter,Cristian Bonvicini,Giuseppe Rossi,Karu Jayathilake,Philip A. Cola,Joseph P. McEvoy,Richard S.E. Keefe,Elizabeth M. C. Fisher,Pamela L. St. Jean,Ina Giegling,Annette M. Hartmann,Hans-Jürgen Möller,Andreas Ruppert,Gillian Fraser,Caroline Crombie,Lefkos T. Middleton,David St Clair,Allen D. Roses,Pierandrea Muglia,Clyde Francks,Dan Rujescu,Herbert Y. Meltzer,David Goldstein +32 more
TL;DR: These data suggest that very few schizophrenia patients share identical genomic causation, potentially complicating efforts to personalize treatment regimens and support the emerging view that rare deleterious variants may be more important in schizophrenia predisposition than common polymorphisms.
Journal ArticleDOI
Correction: A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia
Anna C. Need,Dongliang Ge,Michael E. Weale,Jessica M. Maia,Sheng Feng,Erin L. Heinzen,Kevin V. Shianna,Woohyun Yoon,Dalia Kasperavičiūtė,Massimo Gennarelli,Warren J. Strittmatter,Cristian Bonvicini,Giuseppe Rossi,Karu Jayathilake,Philip A. Cola,Joseph P. McEvoy,Richard S.E. Keefe,Elizabeth M. C. Fisher,Pamela L. St. Jean,Ina Giegling,Annette M. Hartmann,Hans-Jürgen Möller,Andreas Ruppert,Gillian Fraser,Caroline Crombie,Lefkos T. Middleton,David St Clair,Allen D. Roses,Pierandrea Muglia,Clyde Francks,Dan Rujescu,Herbert Y. Meltzer,David Goldstein +32 more
TL;DR: The authors declare the following competing interest: Pamela L. St. Jean, Pierandrea Muglia, and Clyde Francks are full-time employees of GlaxoSmithKline, a pharmaceutical company that has filed patent applications for SNPs related to schizophrenia.