D
Dalia Kasperavičiūtė
Researcher at UCL Institute of Neurology
Publications - 13
Citations - 1727
Dalia Kasperavičiūtė is an academic researcher from UCL Institute of Neurology. The author has contributed to research in topics: Epilepsy & Genome-wide association study. The author has an hindex of 11, co-authored 13 publications receiving 1618 citations. Previous affiliations of Dalia Kasperavičiūtė include University of Liverpool & University College London.
Papers
More filters
Journal ArticleDOI
HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans
Mark McCormack,Ana Alfirevic,Stephane Bourgeois,John J. Farrell,Dalia Kasperavičiūtė,Mary Carrington,Graeme J. Sills,Tony Marson,Xiaoming Jia,Paul I.W. de Bakker,Krishna Chinthapalli,Mariam Molokhia,Marvin Johnson,Gerard D. O'Connor,Elijah Chaila,Saud Alhusaini,Kevin V. Shianna,Rodney A. Radtke,Erin L. Heinzen,Nicole M. Walley,Massimo Pandolfo,Werner J. Pichler,B. Kevin Park,Chantal Depondt,Sanjay M. Sisodiya,David Goldstein,Panos Deloukas,Norman Delanty,Norman Delanty,Gianpiero L. Cavalleri,Munir Pirmohamed +30 more
TL;DR: The presence of the HLA-A*3101 allele was associated with carbamazepine-induced hypersensitivity reactions among subjects of Northern European ancestry.
Journal ArticleDOI
A genome-wide investigation of SNPs and CNVs in schizophrenia
Anna C. Need,Dongliang Ge,Michael E. Weale,Jessica M. Maia,Sheng Feng,Erin L. Heinzen,Kevin V. Shianna,Woohyun Yoon,Dalia Kasperavičiūtė,Massimo Gennarelli,Warren J. Strittmatter,Cristian Bonvicini,Giuseppe Rossi,Karu Jayathilake,Philip A. Cola,Joseph P. McEvoy,Richard S.E. Keefe,Elizabeth M. C. Fisher,Pamela L. St. Jean,Ina Giegling,Annette M. Hartmann,Hans-Jürgen Möller,Andreas Ruppert,Gillian Fraser,Caroline Crombie,Lefkos T. Middleton,David St Clair,Allen D. Roses,Pierandrea Muglia,Clyde Francks,Dan Rujescu,Herbert Y. Meltzer,David Goldstein +32 more
TL;DR: These data suggest that very few schizophrenia patients share identical genomic causation, potentially complicating efforts to personalize treatment regimens and support the emerging view that rare deleterious variants may be more important in schizophrenia predisposition than common polymorphisms.
Journal ArticleDOI
Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A
Dalia Kasperavičiūtė,Claudia B. Catarino,Claudia B. Catarino,Mar Matarin,Costin Leu,Jan Novy,Jan Novy,Anna Tostevin,Anna Tostevin,Bárbara Leal,Ellen V. S. Hessel,Kerstin Hallmann,Michael S. Hildebrand,Hans-Henrik M. Dahl,Mina Ryten,Daniah Trabzuni,Adaikalavan Ramasamy,Adaikalavan Ramasamy,Saud Alhusaini,Saud Alhusaini,Colin P. Doherty,Thomas Dorn,Jörg Hansen,Günter Krämer,Bernhard J. Steinhoff,Dominik Zumsteg,Susan Duncan,Reetta Kälviäinen,Kai Eriksson,Anne-Mari Kantanen,Massimo Pandolfo,Ursula Gruber-Sedlmayr,Kurt Schlachter,Eva M. Reinthaler,Elisabeth Stögmann,Fritz Zimprich,Emilie Théâtre,Colin Smith,Terence J. O'Brien,Terence J. O'Brien,K. Meng Tan,K. Meng Tan,Slavé Petrovski,Slavé Petrovski,Angela Robbiano,Roberta Paravidino,Federico Zara,Pasquale Striano,Michael R. Sperling,Russell J. Buono,Hakon Hakonarson,João Chaves,Paulo Costa,Paulo Costa,Berta Martins da Silva,António Martins da Silva,Pierre N. E. De Graan,Bobby P. C. Koeleman,Albert J. Becker,Susanne Schoch,Marec von Lehe,Philipp S. Reif,Felix Rosenow,Felicitas Becker,Yvonne G. Weber,Holger Lerche,Karl Rössler,Michael Buchfelder,Hajo M. Hamer,Katja Kobow,Roland Coras,Ingmar Blümcke,Ingrid E. Scheffer,Ingrid E. Scheffer,Ingrid E. Scheffer,Samuel F. Berkovic,Michael E. Weale,Norman Delanty,Norman Delanty,Chantal Depondt,Gianpiero L. Cavalleri,Wolfram S. Kunz,Sanjay M. Sisodiya,Sanjay M. Sisodiya +83 more
TL;DR: Genetic analysis and meta-analysis suggest SCN1A involvement in a common epilepsy syndrome, give new direction to biological understanding of mesial temporal lobe epilepsy with hippocampal sclerosis with febrile seizures, and open avenues for investigation of prognostic factors and possible prevention of epilepsy in some children with febs.
Journal ArticleDOI
Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study
Dalia Kasperavičiūtė,Claudia B. Catarino,Erin L. Heinzen,Chantal Depondt,Gianpiero L. Cavalleri,Luis O. Caboclo,Sarah K. Tate,Jenny Jamnadas-Khoda,Krishna Chinthapalli,Lisa M. S. Clayton,Kevin V. Shianna,Rodney A. Radtke,Mohamad A. Mikati,William Gallentine,Aatif M. Husain,Saud Alhusaini,David Leppert,David Leppert,Lefkos T. Middleton,Lefkos T. Middleton,Rachel A. Gibson,Marvin Johnson,Paul M. Matthews,Paul M. Matthews,David A. Hosford,Kjell Heuser,Leslie Amos,Marcos Ortega,Dominik Zumsteg,Heinz Gregor Wieser,Bernhard J. Steinhoff,Günter Krämer,Jörg Hansen,Thomas Dorn,Anne-Mari Kantanen,Leif Gjerstad,Leif Gjerstad,Terhi Peuralinna,Dena G. Hernandez,Kai Eriksson,Reetta Kälviäinen,Colin P. Doherty,Nicholas W. Wood,Massimo Pandolfo,John S. Duncan,Josemir W. Sander,Norman Delanty,David Goldstein,Sanjay M. Sisodiya +48 more
TL;DR: It is shown that, at best, common genetic variation can only have a modest role in predisposition to the partial epilepsies when considered across syndromes in Europeans, and research efforts should also be directed towards identifying the multiple rare variants likely to account for at least part of the heritability of the partial seizures.
Journal ArticleDOI
Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions
Mark McCormack,Thomas J. Urban,Kevin V. Shianna,Nicole M. Walley,Massimo Pandolfo,Chantal Depondt,Elijah Chaila,Gerard D. O'Conner,Dalia Kasperavičiūtė,Rodney A. Radtke,Erin L. Heinzen,Sanjay M. Sisodiya,Norman Delanty,Norman Delanty,Gianpiero L. Cavalleri +14 more
TL;DR: The genome-wide association study results do not support the existence of a clinically relevant common variant for the development of lamotrigine- or phenytoin-induced cADRs, and HLA-A*3101 appears to be specific for carbamazepine-inducedcADRs.