Sheng Feng

TL;DR: A genome-wide association study in a homogenous case-control cohort from Bergen, Norway and evaluated the top 100 single nucleotide polymorphisms (SNPs) in the family-based International COPD Genetics Network found two SNPs at the α-nicotinic acetylcholine receptor (CHRNA 3/5) locus showed unambiguous replication and were significantly associated with lung function in both the ICGN and Boston Early-Onset COPD populations.

TL;DR: These data suggest that very few schizophrenia patients share identical genomic causation, potentially complicating efforts to personalize treatment regimens and support the emerging view that rare deleterious variants may be more important in schizophrenia predisposition than common polymorphisms.

TL;DR: The authors performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects and found common genetic variants explaining down to 1.3% of the variability in viral load at set point.

TL;DR: This study provides overwhelming confirmation of three associations previously reported in a genome-wide study and shows further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC).

TL;DR: This study underscores the paradox of the association between increasing levels of viral load and greater expression of antiviral defense pathways and shows that elite controllers do not have a fully distinctive mRNA expression pattern in CD4+ T cells.