X
Xiangyang Kong
Researcher at Kunming University of Science and Technology
Publications - 36
Citations - 3308
Xiangyang Kong is an academic researcher from Kunming University of Science and Technology. The author has contributed to research in topics: COPD & Genome-wide association study. The author has an hindex of 20, co-authored 32 publications receiving 2940 citations. Previous affiliations of Xiangyang Kong include Research Triangle Park & GlaxoSmithKline.
Papers
More filters
Journal ArticleDOI
A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci
Sreekumar G. Pillai,Dongliang Ge,Guohua Zhu,Xiangyang Kong,Kevin V. Shianna,Anna C. Need,Sheng Feng,Craig P. Hersh,Per Bakke,Amund Gulsvik,Andreas Ruppert,Karin C. Lødrup Carlsen,Allen D. Roses,Allen D. Roses,Wayne Anderson,Stephen I. Rennard,David A. Lomas,Edwin K. Silverman,David Goldstein +18 more
TL;DR: A genome-wide association study in a homogenous case-control cohort from Bergen, Norway and evaluated the top 100 single nucleotide polymorphisms (SNPs) in the family-based International COPD Genetics Network found two SNPs at the α-nicotinic acetylcholine receptor (CHRNA 3/5) locus showed unambiguous replication and were significantly associated with lung function in both the ICGN and Boston Early-Onset COPD populations.
Journal ArticleDOI
Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD
Nancy L. Saccone,Nancy L. Saccone,Robert Culverhouse,Tae-Hwi Schwantes-An,Dale S. Cannon,Xiangning Chen,Sven Cichon,Ina Giegling,Shizhong Han,Younghun Han,Kaisu Keskitalo-Vuokko,Xiangyang Kong,Maria Teresa Landi,Jennie Z. Ma,Susan E. Short,Susan E. Short,Sarah H. Stephens,Victoria L. Stevens,Lingwei Sun,Yufei Wang,Angela S. Wenzlaff,Steven H. Aggen,Naomi Breslau,Peter Broderick,Nilanjan Chatterjee,Jingchun Chen,Andrew C. Heath,Markku Heliövaara,Nicole R. Hoft,David J. Hunter,Majken K. Jensen,Nicholas G. Martin,Grant W. Montgomery,Tianhua Niu,Thomas J. Payne,Leena Peltonen,Michele L. Pergadia,John P. Rice,Richard Sherva,Margaret R. Spitz,Juzhong Sun,Jen C. Wang,Robert B. Weiss,William Wheeler,Stephanie H. Witt,Bao-Zhu Yang,Neil E. Caporaso,Marissa A. Ehringer,Tim Eisen,Susan M. Gapstur,Joel Gelernter,Richard S. Houlston,Jaakko Kaprio,Jaakko Kaprio,Kenneth S. Kendler,Peter Kraft,Mark Leppert,Ming D. Li,Pamela A. F. Madden,Markus M. Nöthen,Sreekumar G. Pillai,Marcella Rietschel,Dan Rujescu,Ann G. Schwartz,Christopher I. Amos,Laura J. Bierut +65 more
TL;DR: This study provides strong evidence that multiple statistically distinct loci in this region affect smoking behavior, and is the first report of association between rs588765 (and correlates) and smoking that achieves genome-wide significance.
Journal ArticleDOI
Variants in FAM13A are associated with chronic obstructive pulmonary disease
Michael H. Cho,Nadia Boutaoui,Barbara J. Klanderman,Jody S. Sylvia,John Ziniti,Craig P. Hersh,Dawn L. DeMeo,Gary M. Hunninghake,Augusto L. Litonjua,David Sparrow,David Sparrow,Christoph Lange,Sungho Won,James Murphy,Terri H. Beaty,Elizabeth A. Regan,Barry J. Make,John E. Hokanson,James D. Crapo,Xiangyang Kong,Wayne Anderson,Ruth Tal-Singer,David A. Lomas,Per Bakke,Amund Gulsvik,Sreekumar G. Pillai,Sreekumar G. Pillai,Edwin K. Silverman +27 more
TL;DR: A new susceptibility locus at 4q22.1 in FAM13A is identified and replicated in three population cohorts, including 2,940 cases and 1,380 controls who were current or former smokers with normal lung function.
Journal ArticleDOI
Genome-wide association study of recurrent major depressive disorder in two European case–control cohorts
Pierandrea Muglia,Federica Tozzi,Nicholas Galwey,Clyde Francks,Clyde Francks,Ruchi Upmanyu,Xiangyang Kong,Athos Antoniades,Athos Antoniades,Enrico Domenici,Julia Perry,Stéphane Rothen,Stéphane Rothen,Caroline L. Vandeleur,Vincent Mooser,Gérard Waeber,Peter Vollenweider,Martin Preisig,Susanne Lucae,Bertram Müller-Myhsok,Florian Holsboer,Lefkos T. Middleton,Lefkos T. Middleton,A. D. Roses,A. D. Roses +24 more
TL;DR: The results from this study suggest that SNPs with substantial odds ratio are unlikely to exist for MDD, at least in the authors' datasets and among the relatively common SNPs genotyped or tagged by the half-million-loci arrays.
Journal ArticleDOI
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13
Michael H. Cho,Peter J. Castaldi,Emily S. Wan,Mateusz Siedlinski,Craig P. Hersh,Dawn L. DeMeo,Blanca E. Himes,Jody S. Sylvia,Barbara J. Klanderman,John Ziniti,Christoph Lange,Augusto A. Litonjua,David Sparrow,David Sparrow,Elizabeth A. Regan,Barry J. Make,John E. Hokanson,Tanda Murray,Jacqueline B. Hetmanski,Sreekumar G. Pillai,Xiangyang Kong,Wayne H. Anderson,Ruth Tal-Singer,David A. Lomas,Harvey O. Coxson,Lisa D. Edwards,William MacNee,Jørgen Vestbo,Julie C. Yates,Alvar Agusti,Peter M.A. Calverley,Bartolome R. Celli,Courtney Crim,Stephen I. Rennard,Emiel F.M. Wouters,Per Bakke,Amund Gulsvik,James D. Crapo,Terri H. Beaty,Edwin K. Silverman +39 more
TL;DR: A new genome-wide significant locus on chromosome 19q13, which includes RAB4B, EGLN2, MIA and CYP2A6, and has previously been identified in association with cigarette smoking behavior is identified.