S
Sreekumar G. Pillai
Researcher at Hoffmann-La Roche
Publications - 58
Citations - 5251
Sreekumar G. Pillai is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: COPD & Population. The author has an hindex of 33, co-authored 56 publications receiving 4909 citations. Previous affiliations of Sreekumar G. Pillai include GlaxoSmithKline & Research Triangle Park.
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Journal ArticleDOI
A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci
Sreekumar G. Pillai,Dongliang Ge,Guohua Zhu,Xiangyang Kong,Kevin V. Shianna,Anna C. Need,Sheng Feng,Craig P. Hersh,Per Bakke,Amund Gulsvik,Andreas Ruppert,Karin C. Lødrup Carlsen,Allen D. Roses,Allen D. Roses,Wayne Anderson,Stephen I. Rennard,David A. Lomas,Edwin K. Silverman,David Goldstein +18 more
TL;DR: A genome-wide association study in a homogenous case-control cohort from Bergen, Norway and evaluated the top 100 single nucleotide polymorphisms (SNPs) in the family-based International COPD Genetics Network found two SNPs at the α-nicotinic acetylcholine receptor (CHRNA 3/5) locus showed unambiguous replication and were significantly associated with lung function in both the ICGN and Boston Early-Onset COPD populations.
Journal ArticleDOI
Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Jason Z. Liu,Federica Tozzi,Dawn M. Waterworth,Sreekumar G. Pillai,Pierandrea Muglia,Lefkos T. Middleton,Wade H. Berrettini,Christopher W. Knouff,Xin Yuan,Gérard Waeber,Peter Vollenweider,Martin Preisig,Nicholas J. Wareham,Jing Hua Zhao,Ruth J. F. Loos,Ins Barroso,Kay-Tee Khaw,Scott M. Grundy,Philip J. Barter,Robert W. Mahley,Antero Kesäniemi,Ruth McPherson,John B. Vincent,John Strauss,James L. Kennedy,Anne Farmer,Peter McGuffin,Richard O. Day,Keith Matthews,Per Bakke,Amund Gulsvik,Susanne Lucae,Marcus Ising,T. Brueckl,S. Horstmann,H.-Erich Wichmann,Rajesh Rawal,Norbert Dahmen,Claudia Lamina,Ozren Polasek,Lina Zgaga,Jennifer E. Huffman,Susan Campbell,Jaspal S. Kooner,John C. Chambers,Mary Susan Burnett,Joseph M. Devaney,Augusto D. Pichard,Kenneth M. Kent,Lowell F. Satler,Joseph M. Lindsay,Ron Waksman,Stephen E. Epstein,James F. Wilson,Sarah H. Wild,Harry Campbell,Veronique Vitart,Muredach P. Reilly,Mingyao Li,Liming Qu,Robert L. Wilensky,William H. Matthai,Hakon Hakonarson,Daniel J. Rader,Andre Franke,Michael Wittig,Arne Schäfer,Manuela Uda,Antonio Terracciano,Xiangjun Xiao,Fabio Busonero,Paul Scheet,David Schlessinger,David St Clair,Dan Rujescu,Gonçalo R. Abecasis,Hans J. Grabe,Alexander Teumer,Henry Völzke,Astrid Petersmann,Ulrich John,Igor Rudan,Igor Rudan,Caroline Hayward,Alan F. Wright,Ivana Kolcic,Benjamin J. Wright,John R. Thompson,Anthony J. Balmforth,Alistair S. Hall,Nilesh J. Samani,Carl A. Anderson,Tariq Ahmad,Christopher G. Mathew,Miles Parkes,Jack Satsangi,Mark J. Caulfield,Patricia B. Munroe,Martin Farrall,Anna F. Dominiczak,Jane Worthington,Wendy Thomson,Steve Eyre,Anne Barton,Vincent Mooser,Clyde Francks,Clyde Francks,Jonathan Marchini +107 more
TL;DR: The Oxford-GlaxoSmithKline study (Ox-GSK) as discussed by the authors performed a genome-wide meta-analysis of SNP association with smoking-related behavioral traits and found an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19) that includes CHRNA5, CHRNA3 and CHRNB4.
Journal ArticleDOI
Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD
Nancy L. Saccone,Nancy L. Saccone,Robert Culverhouse,Tae-Hwi Schwantes-An,Dale S. Cannon,Xiangning Chen,Sven Cichon,Ina Giegling,Shizhong Han,Younghun Han,Kaisu Keskitalo-Vuokko,Xiangyang Kong,Maria Teresa Landi,Jennie Z. Ma,Susan E. Short,Susan E. Short,Sarah H. Stephens,Victoria L. Stevens,Lingwei Sun,Yufei Wang,Angela S. Wenzlaff,Steven H. Aggen,Naomi Breslau,Peter Broderick,Nilanjan Chatterjee,Jingchun Chen,Andrew C. Heath,Markku Heliövaara,Nicole R. Hoft,David J. Hunter,Majken K. Jensen,Nicholas G. Martin,Grant W. Montgomery,Tianhua Niu,Thomas J. Payne,Leena Peltonen,Michele L. Pergadia,John P. Rice,Richard Sherva,Margaret R. Spitz,Juzhong Sun,Jen C. Wang,Robert B. Weiss,William Wheeler,Stephanie H. Witt,Bao-Zhu Yang,Neil E. Caporaso,Marissa A. Ehringer,Tim Eisen,Susan M. Gapstur,Joel Gelernter,Richard S. Houlston,Jaakko Kaprio,Jaakko Kaprio,Kenneth S. Kendler,Peter Kraft,Mark Leppert,Ming D. Li,Pamela A. F. Madden,Markus M. Nöthen,Sreekumar G. Pillai,Marcella Rietschel,Dan Rujescu,Ann G. Schwartz,Christopher I. Amos,Laura J. Bierut +65 more
TL;DR: This study provides strong evidence that multiple statistically distinct loci in this region affect smoking behavior, and is the first report of association between rs588765 (and correlates) and smoking that achieves genome-wide significance.
Journal ArticleDOI
Variants in FAM13A are associated with chronic obstructive pulmonary disease
Michael H. Cho,Nadia Boutaoui,Barbara J. Klanderman,Jody S. Sylvia,John Ziniti,Craig P. Hersh,Dawn L. DeMeo,Gary M. Hunninghake,Augusto L. Litonjua,David Sparrow,David Sparrow,Christoph Lange,Sungho Won,James Murphy,Terri H. Beaty,Elizabeth A. Regan,Barry J. Make,John E. Hokanson,James D. Crapo,Xiangyang Kong,Wayne Anderson,Ruth Tal-Singer,David A. Lomas,Per Bakke,Amund Gulsvik,Sreekumar G. Pillai,Sreekumar G. Pillai,Edwin K. Silverman +27 more
TL;DR: A new susceptibility locus at 4q22.1 in FAM13A is identified and replicated in three population cohorts, including 2,940 cases and 1,380 controls who were current or former smokers with normal lung function.
Journal ArticleDOI
Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease.
Bipen D. Patel,Harvey O. Coxson,Sreekumar G. Pillai,Alvar Agusti,Peter M.A. Calverley,Claudio F. Donner,Barry Make,Nestor L. Müller,Stephen I. Rennard,Jørgen Vestbo,Emiel F.M. Wouters,Melanie P. Hiorns,Yasutaka Nakano,Pat G. Camp,Paola V. Nasute Fauerbach,Nicholas J. Screaton,Edward J. Campbell,Wayne H. Anderson,Peter D. Paré,Robert D. Levy,Stephen L. Lake,Edwin K. Silverman,David A. Lomas +22 more
TL;DR: Airway wall thickening and emphysema make independent contributions to airflow obstruction in COPD and these phenotypes show independent aggregation within families of individuals with COPD, suggesting that different genetic factors influence these disease processes.