A
Andres Alonso
Researcher at Spanish National Research Council
Publications - 52
Citations - 5541
Andres Alonso is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Protein tyrosine phosphatase & Phosphatase. The author has an hindex of 29, co-authored 50 publications receiving 5294 citations. Previous affiliations of Andres Alonso include University of Valladolid & Complutense University of Madrid.
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Journal ArticleDOI
Protein Tyrosine Phosphatases in the Human Genome
Andres Alonso,Joanna Sasin,Nunzio Bottini,Ilan Friedberg,Iddo Friedberg,Andrei L. Osterman,Adam Godzik,Tony Hunter,Jack E. Dixon,Tomas Mustelin +9 more
TL;DR: The set of 107 genes in the human genome that encode members of the four protein tyrosine phosphatase (PTP) families are presented and the role of these enzymes in human disease will be discussed.
Journal ArticleDOI
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
Nunzio Bottini,Lucia Musumeci,Andres Alonso,Souad Rahmouni,Konstantina Nika,Masoud Rostamkhani,James P. MacMurray,Gian Franco Meloni,Paola Lucarelli,Maurizio Pellecchia,George S. Eisenbarth,David E. Comings,Tomas Mustelin +12 more
TL;DR: A single-nucleotide polymorphism in the gene (PTPN22) encoding the lymphoid protein tyrosine phosphatase (LYP), a suppressor of T-cell activation, is associated with type 1 diabetes mellitus (T1D).
Journal ArticleDOI
Inhibitory role for dual specificity phosphatase VHR in T cell antigen receptor and CD28-induced Erk and Jnk activation.
TL;DR: The results suggest that VHR is a negative regulator of the Erk and Jnk pathways in T cells and, therefore, may play a role in aspects of T lymphocyte physiology that depend on these kinases.
Journal ArticleDOI
Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence.
Souad Rahmouni,Fabio Cerignoli,Andres Alonso,Andres Alonso,Toshiya Tsutji,Rachel Henkens,Changjun Zhu,Christine Louis-dit-Sully,Michel Moutschen,Wei Jiang,Tomas Mustelin +10 more
TL;DR: It is concluded that VHR is required for cell-cycle progression as it modulates MAP kinase activation in a cell- cycle phase-dependent manner.
Journal ArticleDOI
Subcellular localization of intracellular protein tyrosine phosphatases in T cells.
Anette Gjörloff-Wingren,Manju Saxena,Shulin Han,Xiaodong Wang,Andres Alonso,Marta Renedo,Phil Oh,Scott Williams,Jan E. Schnitzer,Tomas Mustelin +9 more
TL;DR: Overexpression of 6 of the PTPases reduced IL‐2 gene activation, 3 of them thereby identified as novel candidates for negative regulators of TCR signaling.