Protein Tyrosine Phosphatases in the Human Genome
Andres Alonso,Joanna Sasin,Nunzio Bottini,Ilan Friedberg,Iddo Friedberg,Andrei L. Osterman,Adam Godzik,Tony Hunter,Jack E. Dixon,Tomas Mustelin +9 more
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TLDR
The set of 107 genes in the human genome that encode members of the four protein tyrosine phosphatase (PTP) families are presented and the role of these enzymes in human disease will be discussed.About:
This article is published in Cell.The article was published on 2004-06-11 and is currently open access. It has received 1793 citations till now. The article focuses on the topics: Protein tyrosine phosphatase & Receptor-Like Protein Tyrosine Phosphatases.read more
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Journal ArticleDOI
Protein tyrosine phosphatases: from genes, to function, to disease
TL;DR: Recent breakthroughs in understanding of the role of the PTPs in the regulation of signal transduction and the aetiology of human disease are described.
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Differential regulation and properties of MAPKs.
TL;DR: Some of the properties of the three major MAPK pathways are described and discussed and how these properties govern pathway regulation and activity are discussed.
Journal ArticleDOI
Mechanisms of specificity in protein phosphorylation
TL;DR: A typical protein kinase must recognize between one and a few hundred bona fide phosphorylation sites in a background of ∼700,000 potentially phosphorylatable residues.
Journal ArticleDOI
ERK1/2 MAP kinases: structure, function, and regulation.
TL;DR: The activity of the Ras-Raf-MEK-ERK cascade is increased in about one-third of all human cancers, and inhibition of components of this cascade by targeted inhibitors represents an important anti-tumor strategy.
Journal ArticleDOI
Serine/Threonine Phosphatases: Mechanism through Structure
TL;DR: Biochemical and structural investigations that advance the mechanistic understanding of the three major classes of PSPs are discussed, with a focus on PP2A.
References
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Journal ArticleDOI
The Protein Kinase Complement of the Human Genome
TL;DR: The protein kinase complement of the human genome is catalogued using public and proprietary genomic, complementary DNA, and expressed sequence tag sequences to provide a starting point for comprehensive analysis of protein phosphorylation in normal and disease states and a detailed view of the current state of human genome analysis through a focus on one large gene family.
Journal ArticleDOI
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.
Mounib Elchebly,Paul Payette,Eva Michaliszyn,Wanda Cromlish,Susan Collins,Ailsa Lee Loy,Denis Normandin,Alan Cheng,Jean Himms-Hagen,Chi-Chung Chan,Chidambaram Ramachandran,Michael J. Gresser,Michel L. Tremblay,Brian P. Kennedy +13 more
TL;DR: In this article, the mouse homolog of the gene encoding PTP-1B yielded healthy mice that, in the fed state, had blood glucose concentrations that were slightly lower and concentrations of circulating insulin that were one-half those of their PTP−1B+/+ littermates.
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Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
Danny Liaw,Deborah J. Marsh,Jing Li,Patricia L. M. Dahia,Steven I. Wang,Z. Zheng,Shikha Bose,K. M. Call,Hui C. Tsou,Monica Peacocke,Charis Eng,Ramon Parsons +11 more
TL;DR: Mutational analysis of PTEN in CD kindreds has identified germline mutations that are predicted to disrupt the protein tyrosine/dual-specificity phosphatase domain of this gene, and implies that PTEN may play a role in organizing the relationship of different cell types within an organ during development.
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Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome.
Marco Tartaglia,Marco Tartaglia,Ernest L. Mehler,Rosalie Goldberg,Giuseppe Zampino,Han G. Brunner,Hannie Kremer,Ineke van der Burgt,Andrew H. Crosby,Andra Ion,Steve Jeffery,Kamini Kalidas,Michael A. Patton,Raju Kucherlapati,Bruce D. Gelb +14 more
TL;DR: It is shown that missense mutations in PTPN11—a gene encoding the nonreceptor protein tyrosine phosphatase SHP-2, which contains two Src homology 2 (SH2) domains—cause Noonan syndrome and account for more than 50% of the cases that were examined.
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A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
Nunzio Bottini,Lucia Musumeci,Andres Alonso,Souad Rahmouni,Konstantina Nika,Masoud Rostamkhani,James P. MacMurray,Gian Franco Meloni,Paola Lucarelli,Maurizio Pellecchia,George S. Eisenbarth,David E. Comings,Tomas Mustelin +12 more
TL;DR: A single-nucleotide polymorphism in the gene (PTPN22) encoding the lymphoid protein tyrosine phosphatase (LYP), a suppressor of T-cell activation, is associated with type 1 diabetes mellitus (T1D).