J
Jane Lamerdin
Researcher at Lawrence Livermore National Laboratory
Publications - 65
Citations - 12742
Jane Lamerdin is an academic researcher from Lawrence Livermore National Laboratory. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 35, co-authored 65 publications receiving 12152 citations. Previous affiliations of Jane Lamerdin include Joint Genome Institute.
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Journal ArticleDOI
Familial Hemiplegic Migraine and Episodic Ataxia Type-2 Are Caused by Mutations in the Ca2+ Channel Gene CACNL1A4
Roel A. Ophoff,Gisela M. Terwindt,Monique N. Vergouwe,Ronald van Eijk,Peter J. Oefner,Susan M.G. Hoffman,Jane Lamerdin,Harvey W. Mohrenweiser,Dennis E. Bulman,Maurizio Ferrari,Joost Haan,Dick Lindhout,Gert-Jan B. van Ommen,Marten H. Hofker,Michel D. Ferrari,Rune R. Frants +15 more
TL;DR: A brain-specific P/Q-type Ca2+ channel alpha1-subunit gene, CACNL1A4, covering 300 kb with 47 exons is characterized, revealing polymorphic variations, including a (CA)n-repeat (D19S1150), a (CAG) n-repeat in the 3'-UTR, and different types of deleterious mutations in FHM and EA-2.
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Positionally Cloned Gene for a Novel Glomerular Protein—Nephrin—Is Mutated in Congenital Nephrotic Syndrome
Marjo Kestilä,Ulla Lenkkeri,Minna Männikkö,Jane Lamerdin,Paula McCready,Heli Putaala,Vesa Ruotsalainen,Takako Morita,Marja Nissinen,Riitta Herva,Clifford E. Kashtan,Leena Peltonen,Christer Holmberg,Anne S. Olsen,Karl Tryggvason,Karl Tryggvason +15 more
TL;DR: A crucial role for this protein in the development or function of the kidney filtration barrier is demonstrated and by Northern and in situ hybridization was shown to be specifically expressed in renal glomeruli.
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Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation
Gabrielle Rocap,Frank W. Larimer,Frank W. Larimer,Jane Lamerdin,Stephanie Malfatti,Patrick S. G. Chain,Patrick S. G. Chain,Nathan A. Ahlgren,Andrae Arellano,Maureen L. Coleman,Loren Hauser,Loren Hauser,Wolfgang R. Hess,Zackary I. Johnson,Miriam Land,Miriam Land,Debbie Lindell,Anton F. Post,Warren Regala,Manesh Shah,Manesh Shah,Stephanie L. Shaw,Claudia Steglich,Matthew B. Sullivan,Claire S. Ting,Andrew C. Tolonen,Eric A. Webb,Erik R. Zinser,Sallie W. Chisholm +28 more
TL;DR: The genomes of two Prochlorococcus strains that span the largest evolutionary distance within the Pro chlorococcus lineage are compared and reveal dynamic genomes that are constantly changing in response to myriad selection pressures.
Journal ArticleDOI
Complete genome sequence of the metabolically versatile photosynthetic bacterium Rhodopseudomonas palustris
Frank W. Larimer,Patrick S. G. Chain,Patrick S. G. Chain,Loren Hauser,Loren Hauser,Jane Lamerdin,Stephanie Malfatti,Stephanie Malfatti,Long Do,Miriam Land,Miriam Land,Dale A. Pelletier,Dale A. Pelletier,Thomas Beatty,Andrew S. Lang,F. Robert Tabita,Janet L. Gibson,Thomas E. Hanson,Cedric E. Bobst,Janelle L. Torres Y. Torres,Caroline M. Peres,Faith H. Harrison,Jane Gibson,Caroline S. Harwood +23 more
TL;DR: The genome sequence of R. palustris is described, which reveals genes that confer a remarkably large number of options within a given type of metabolism, including three nitrogenases, five benzene ring cleavage pathways and four light harvesting 2 systems.
Journal ArticleDOI
The genome of a motile marine Synechococcus
Brian Palenik,B. Brahamsha,Frank W. Larimer,Frank W. Larimer,Miriam Land,Miriam Land,Loren Hauser,Loren Hauser,Patrick S. G. Chain,Patrick S. G. Chain,Jane Lamerdin,Jane Lamerdin,Warren Regala,Warren Regala,Eric E. Allen,Eric E. Allen,Jay McCarren,Ian T. Paulsen,Alexis Dufresne,Frédéric Partensky,Eric A. Webb,John B. Waterbury +21 more
TL;DR: The genome of WH8102 seems to have been greatly influenced by horizontal gene transfer, partially through phages, and is more of a generalist than two related marine cyanobacteria.