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Bernd H. Zinselmeyer
Researcher at Washington University in St. Louis
Publications - 70
Citations - 5855
Bernd H. Zinselmeyer is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: T cell & Immune system. The author has an hindex of 35, co-authored 68 publications receiving 4766 citations. Previous affiliations of Bernd H. Zinselmeyer include National Institutes of Health & University of Glasgow.
Papers
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Journal ArticleDOI
TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
Yaming Wang,Yaming Wang,Marina Cella,Kaitlin Mallinson,Jason D. Ulrich,Katherine L. Young,Michelle L. Robinette,Susan Gilfillan,Gokul M. Krishnan,Shwetha Sudhakar,Bernd H. Zinselmeyer,David M. Holtzman,John R. Cirrito,Marco Colonna +13 more
TL;DR: It is found that TREM2 deficiency and haploinsufficiency augment β-amyloid accumulation due to dysfunctional response of microglia, which become apoptotic and fail to cluster around Aβ plaques.
Journal ArticleDOI
Reversal of the TCR stop signal by CTLA-4.
Helga Schneider,Helga Schneider,Jos Downey,Andrew M. Smith,Bernd H. Zinselmeyer,Bernd H. Zinselmeyer,Catherine M. Rush,Catherine M. Rush,James M. Brewer,James M. Brewer,Bin Wei,Nancy Hogg,Paul Garside,Paul Garside,Christopher E. Rudd,Christopher E. Rudd +15 more
TL;DR: It is shown that CTLA-4 increases T cell motility and overrides the T cell receptor (TCR)–induced stop signal required for stable conjugate formation between T cells and antigen-presenting cells, which suggests a fundamentally different model of reverse stop signaling.
Journal ArticleDOI
In vivo two-photon imaging reveals monocyte-dependent neutrophil extravasation during pulmonary inflammation
Daniel Kreisel,Ruben G. Nava,Wenjun Li,Bernd H. Zinselmeyer,Baomei Wang,J. Lai,Robert Pless,Andrew E. Gelman,Alexander S. Krupnick,Mark J. Miller +9 more
TL;DR: It is found that the lungs contained a significant pool of tissue-resident neutrophils in the steady state and a subset of monocytes serve as key regulators of neutrophil extravasation in the lung and may be an attractive target for the treatment of inflammatory pulmonary diseases.
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The lower-generation polypropylenimine dendrimers are effective gene-transfer agents.
TL;DR: The generation 2 polypropylenimine dendrimer combines a sufficient level of DNA binding with a low level of cell cytoxicity to give it optimum in vitro gene transfer activity.
Journal ArticleDOI
The Lymphatic System: Integral Roles in Immunity.
TL;DR: It is argued that to consider the impact of lymphatic biology in any given immunological interaction is a key step toward integrating immunology with organ physiology and ultimately many complex pathologies.