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Andrew S. Brack
Researcher at University of California, San Francisco
Publications - 47
Citations - 8524
Andrew S. Brack is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Stem cell & Skeletal muscle. The author has an hindex of 27, co-authored 47 publications receiving 7526 citations. Previous affiliations of Andrew S. Brack include University of California, Berkeley & Harvard University.
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Journal ArticleDOI
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA
Luigi Warren,Philip D. Manos,Philip D. Manos,Tim Ahfeldt,Tim Ahfeldt,Yuin-Han Loh,Hu Li,Hu Li,Frank H. Lau,Wataru Ebina,Pankaj Mandal,Zachary D. Smith,Alexander Meissner,Alexander Meissner,George Q. Daley,Andrew S. Brack,James J. Collins,James J. Collins,James J. Collins,Chad A. Cowan,Thorsten M. Schlaeger,Thorsten M. Schlaeger,Derrick J. Rossi +22 more
TL;DR: It is shown that this approach can reprogram multiple human cell types to pluripotency with efficiencies that greatly surpass established protocols and represents a safe, efficient strategy for somatic cell reprogramming and directing cell fate that has broad applicability for basic research, disease modeling, and regenerative medicine.
Journal ArticleDOI
Increased Wnt Signaling During Aging Alters Muscle Stem Cell Fate and Increases Fibrosis
Andrew S. Brack,Michael J. Conboy,Sudeep Roy,Mark Lee,Calvin J. Kuo,Charles Keller,Thomas A. Rando,Thomas A. Rando +7 more
TL;DR: It is shown that muscle stem cells from aged mice tend to convert from a myogenic to a fibrogenic lineage as they begin to proliferate and that this conversion is mediated by factors in the systemic environment of the old animals.
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The aged niche disrupts muscle stem cell quiescence
TL;DR: It is demonstrated that the aged muscle stem cell niche, the muscle fibre, expresses Fgf2 under homeostatic conditions, driving a subset of satellite cells to break quiescence and lose their self-renewing capacity.
Journal ArticleDOI
A Temporal Switch from Notch to Wnt Signaling in Muscle Stem Cells Is Necessary for Normal Adult Myogenesis
Andrew S. Brack,Irina M. Conboy,Michael J. Conboy,Jeanne Shen,Thomas A. Rando,Thomas A. Rando +5 more
TL;DR: It is demonstrated that the temporal balance between Notch and Wnt signaling orchestrates the precise progression of muscle precursor cells along the myogenic lineage pathway, through stages of proliferative expansion and then differentiation, during postnatal myogenesis.
Journal ArticleDOI
GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration.
Marc A. Egerman,Samuel M. Cadena,Jason A. Gilbert,Angelika Meyer,Hallie N. Nelson,Susanne E. Swalley,Carolyn Mallozzi,Carsten Jacobi,Lori L. Jennings,Ieuan Clay,Gaëlle Laurent,Shenglin Ma,Sophie Brachat,Estelle Lach-Trifilieff,Tea Shavlakadze,Anne-Ulrike Trendelenburg,Andrew S. Brack,David J. Glass +17 more
TL;DR: A GDF11-specific immunoassay is developed and a trend toward increased GDF 11 levels in sera of aged rats and humans is shown and GDF12 could be a target for pharmacologic blockade to treat age-related sarcopenia.