A
Andrew Willems
Researcher at University of Toronto
Publications - 19
Citations - 7206
Andrew Willems is an academic researcher from University of Toronto. The author has contributed to research in topics: Ubiquitin ligase & Cell division control protein 4. The author has an hindex of 12, co-authored 16 publications receiving 6987 citations. Previous affiliations of Andrew Willems include Mount Sinai Hospital, Toronto & Mount Sinai Hospital.
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Journal ArticleDOI
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
Yuen Ho,Albrecht Gruhler,Adrian Heilbut,Gary D. Bader,Gary D. Bader,Lynda Moore,Sally-Lin Adams,Anna Millar,Paul J. Taylor,Keiryn L. Bennett,Kelly Boutilier,Lingyun Yang,Cheryl Wolting,Ian Donaldson,Søren Schandorff,Juanita Shewnarane,Mai Vo,Joanne Taggart,Marilyn Goudreault,Brenda Muskat,Cris Alfarano,Danielle Dewar,Zhen Lin,Katerina Michalickova,Katerina Michalickova,Andrew Willems,Andrew Willems,Holly Sassi,Peter A Nielsen,Karina Juhl Rasmussen,Jens R. Andersen,Lene E. Johansen,Lykke Haastrup Hansen,Hans Jespersen,Alexandre V. Podtelejnikov,Eva Nielsen,Janne S. Crawford,Vibeke Poulsen,Birgitte D Sørensen,Jesper Matthiesen,Ronald C. Hendrickson,Frank Gleeson,Tony Pawson,Tony Pawson,Michael Moran,Daniel Durocher,Daniel Durocher,Matthias Mann,Christopher W. V. Hogue,Christopher W. V. Hogue,Daniel Figeys,Mike Tyers,Mike Tyers +52 more
TL;DR: Comparison of the HMS-PCI data set with interactions reported in the literature revealed an average threefold higher success rate in detection of known complexes compared with large-scale two-hybrid studies.
Journal ArticleDOI
Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis
TL;DR: A vast array of F- box proteins have been revealed by genome sequencing projects, and the early returns from genetic analysis in several organisms promise that F-box proteins will participate in the regulation of many processes, including cell division, transcription, signal transduction and development.
Journal ArticleDOI
Structural Basis for Phosphodependent Substrate Selection and Orientation by the SCFCdc4 Ubiquitin Ligase
Stephen Orlicky,Xiaojing Tang,Andrew Willems,Mike Tyers,Mike Tyers,Frank Sicheri,Frank Sicheri +6 more
TL;DR: A 2.7-ray crystal structure of a Skp1-Cdc4 complex bound to a high-affinity CPD phosphopeptide from human cyclin E reveals a core CPD motif, Leu-Leu-pThr-Pro, bound to an eight-bladed WD40 propeller domain in Cdc4.
Journal ArticleDOI
A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin.
TL;DR: Structural insights into SCF-like complexes have begun to illuminate aspects of substrate recognition and catalytic reaction mechanisms.
Journal ArticleDOI
The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase.
Lionel Pintard,John H. Willis,Andrew Willems,Jacque-Lynne Johnson,Martin Srayko,Martin Srayko,Thimo Kurz,Sarah Glaser,Paul E. Mains,Mike Tyers,Bruce Bowerman,Matthias Peter +11 more
TL;DR: The BTB-containing protein MEL-26 is identified as a component required for degradation of MEI-1 in vivo and in vitro, and displays properties of a substrate-specific adaptor in Cul3-based E3-ubiquitin ligases.