B
Bruce Bowerman
Researcher at University of Oregon
Publications - 24
Citations - 7124
Bruce Bowerman is an academic researcher from University of Oregon. The author has contributed to research in topics: Gene & Wnt signaling pathway. The author has an hindex of 22, co-authored 22 publications receiving 6923 citations. Previous affiliations of Bruce Bowerman include University of California, San Francisco & Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
The Promise and Perils of Wnt Signaling Through β-Catenin
TL;DR: The STKE Connections Maps for these pathways provide an important tool in accessing this large body of complex information about Wnt pathways both in canonical terms and at the species level.
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The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF
Tohru Ishitani,Jun Ninomiya-Tsuji,Shln Ichl Nagai,Michiru Nishita,Marc D. Meneghini,Nick Barker,Marian L. Waterman,Bruce Bowerman,Hans Clevers,Hiroshi Shibuya,Kunihiro Matsumoto +10 more
TL;DR: It is shown that TAK1 activation stimulates NLK activity and downregulates transcriptional activation mediated by β-catenin and TCF, which negatively regulates the Wnt signalling pathway.
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Wnt Signaling Polarizes an Early C. elegans Blastomere to Distinguish Endoderm from Mesoderm
TL;DR: Defective mitotic spindle orientations in mom mutant embryos indicate that Wnt signaling influences cytoskeletal polarity in blastomeres throughout the early embryo.
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Correct integration of retroviral DNA in vitro
TL;DR: A cell-free system for studying the integration of retroviral DNA and amber mutations in a bacteriophage lambda genome that serves as the target for integration are suppressed by integration of an MLV derivative that carries the E. coli supF gene.
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The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase.
Lionel Pintard,John H. Willis,Andrew Willems,Jacque-Lynne Johnson,Martin Srayko,Martin Srayko,Thimo Kurz,Sarah Glaser,Paul E. Mains,Mike Tyers,Bruce Bowerman,Matthias Peter +11 more
TL;DR: The BTB-containing protein MEL-26 is identified as a component required for degradation of MEI-1 in vivo and in vitro, and displays properties of a substrate-specific adaptor in Cul3-based E3-ubiquitin ligases.