W
William Grey
Researcher at Francis Crick Institute
Publications - 24
Citations - 1161
William Grey is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Haematopoiesis & Myeloid leukemia. The author has an hindex of 7, co-authored 17 publications receiving 876 citations. Previous affiliations of William Grey include King's College London.
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Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C
Borbala Mifsud,Filipe Tavares-Cadete,Alice N Young,Robert Sugar,Stefan Schoenfelder,Lauren Ferreira,Steven W. Wingett,Simon Andrews,William Grey,Philip Ewels,Bram Herman,Scott Happe,Andy Higgs,Emily M LeProust,George A. Follows,Peter Fraser,Nicholas M. Luscombe,Cameron S. Osborne +17 more
TL;DR: In this article, the authors use Capture Hi-C (CHi-C) to examine the long-range interactions of almost 22,000 promoters in 2 human blood cell types and identify over 1.6 million shared and cell type-restricted interactions spanning hundreds of kilobases between promoters and distal loci.
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Modeling the human bone marrow niche in mice: From host bone marrow engraftment to bioengineering approaches.
Ander Abarrategi,Syed A Mian,Syed A Mian,Diana Passaro,Kevin Rouault-Pierre,Kevin Rouault-Pierre,William Grey,Dominique Bonnet +7 more
TL;DR: The latest major improvement has been the use of human bone marrow niche–forming cells to generate human–mouse chimeric BM tissues in PDXs, which can shed light on the interactions between human stroma and hematopoietic cells.
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Human Erythroid Progenitors Are Directly Infected by SARS-CoV-2: Implications for Emerging Erythropoiesis in Severe COVID-19 Patients.
Hector Huerga Encabo,William Grey,Manuel Garcia-Albornoz,Henry Wood,Henry Wood,Rachel Ulferts,Iker Valle Aramburu,Austin G. Kulasekararaj,Ghulam J. Mufti,Venizelos Papayannopoulos,Rupert Beale,Dominique Bonnet +11 more
TL;DR: In this article, the authors showed that ACE2 expression peaks during erythropoiesis and renders erythroid progenitors vulnerable to infection by SARS-CoV-2.
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The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia
Alessandro Di Tullio,Kevin Rouault-Pierre,Kevin Rouault-Pierre,Ander Abarrategi,Syed A Mian,Syed A Mian,William Grey,John G. Gribben,Aengus Stewart,Elizabeth Blackwood,Dominique Bonnet +10 more
TL;DR: The authors show that the CHK1 inhibitor GDC-0575 in combination with cytarabine and G-CSF has a significant anti-leukemic effect without toxicity to normal marrow stem and progenitor cells.
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High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia.
Miriam Marquis,Cyrielle Beaubois,Vincent-Philippe Lavallée,Michal Abrahamowicz,Coraline Danieli,Sébastien Lemieux,Imran Ahmad,Andrew H. Wei,Andrew H. Wei,Stephen B. Ting,Stephen B. Ting,Shaun Fleming,Anthony P. Schwarer,David Grimwade,David Grimwade,William Grey,Robert Kerrin Hills,Robert Kerrin Hills,Paresh Vyas,Nigel H. Russell,Nigel H. Russell,Guy Sauvageau,Josée Hébert +22 more
TL;DR: The HMGA2 test could be implemented in clinical trials developing novel therapeutic strategies for high-risk AML, including in the intermediate cytogenetic risk category.