G
George A. Follows
Researcher at University of Cambridge
Publications - 62
Citations - 5202
George A. Follows is an academic researcher from University of Cambridge. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 21, co-authored 40 publications receiving 4435 citations. Previous affiliations of George A. Follows include St James's University Hospital & University of Bologna.
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Journal ArticleDOI
Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development
Philip J. Stephens,Christopher Greenman,Beiyuan Fu,Fengtang Yang,Graham R. Bignell,Laura Mudie,Erin Pleasance,King Wai Lau,David Beare,Lucy Stebbings,Stuart McLaren,Meng-Lay Lin,David J. McBride,Ignacio Varela,Serena Nik-Zainal,Catherine Leroy,Mingming Jia,Andrew Menzies,Adam Butler,Jon W. Teague,Michael A. Quail,John Burton,Harold Swerdlow,Nigel P. Carter,Laura Morsberger,Christine A. Iacobuzio-Donahue,George A. Follows,Anthony R. Green,Adrienne M. Flanagan,Adrienne M. Flanagan,Michael R. Stratton,P. Andrew Futreal,Peter J. Campbell,Peter J. Campbell +33 more
TL;DR: It is found that one, or indeed more than one, cancer-causing lesion can emerge out of the genomic crisis, which has important implications for the origins of genomic remodeling and temporal emergence of cancer.
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Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C
Borbala Mifsud,Filipe Tavares-Cadete,Alice N Young,Robert Sugar,Stefan Schoenfelder,Lauren Ferreira,Steven W. Wingett,Simon Andrews,William Grey,Philip Ewels,Bram Herman,Scott Happe,Andy Higgs,Emily M LeProust,George A. Follows,Peter Fraser,Nicholas M. Luscombe,Cameron S. Osborne +17 more
TL;DR: In this article, the authors use Capture Hi-C (CHi-C) to examine the long-range interactions of almost 22,000 promoters in 2 human blood cell types and identify over 1.6 million shared and cell type-restricted interactions spanning hundreds of kilobases between promoters and distal loci.
Journal ArticleDOI
Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing
Peter J. Campbell,Erin Pleasance,Philip J. Stephens,Ed Dicks,Richard Rance,Ian Goodhead,George A. Follows,Anthony R. Green,P. Andy Futreal,Michael R. Stratton +9 more
TL;DR: The potential for ultra-deep resequencing to recapitulate the dynamics of clonal evolution in cancer cell populations is demonstrated and an algorithm to differentiate genuine haplotypes of somatic hypermutations from such artifacts is developed.
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Phosphatidylinositol 3-Kinase Inhibition by Copanlisib in Relapsed or Refractory Indolent Lymphoma.
Martin Dreyling,Armando Santoro,Luigina Mollica,Sirpa Leppä,George A. Follows,Georg Lenz,Won Seog Kim,Arnon Nagler,Panayiotis Panayiotidis,Judit Demeter,Muhit Ozcan,Marina Kosinova,Krimo Bouabdallah,Franck Morschhauser,Don A. Stevens,David Trevarthen,Marius Giurescu,Lisa Cupit,Li Liu,Karl Köchert,Henrik Seidel,Carol Peña,Shuxin Yin,Florian Hiemeyer,J. Garcia-Vargas,Barrett H. Childs,Pier Luigi Zinzani +26 more
TL;DR: High response rates to copanlisib were associated with high expression of PI3K/B-cell receptor signaling pathway genes, and this phase II study demonstrated significant efficacy and a manageable safety profile in heavily pretreated patients with relapsed or refractory indolent lymphoma.
Journal ArticleDOI
Primary Testicular Lymphoma
TL;DR: Evidence supporting combination chemotherapy and radiotherapy in primary testicular non-Hodgkin lymphoma is discussed, which supports the use of orchidectomy followed by Rituximab- cyclophosphamide, doxorubicin, vincristine and prednisolone and prophylactic radiotherapy to the contralateral testis with or without nodal radiotherapy.