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Angela Orecchia
Researcher at University of Nice Sophia Antipolis
Publications - 16
Citations - 1346
Angela Orecchia is an academic researcher from University of Nice Sophia Antipolis. The author has contributed to research in topics: Vascular endothelial growth factor A & Vascular endothelial growth factor B. The author has an hindex of 12, co-authored 16 publications receiving 1245 citations.
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Journal ArticleDOI
Corneal avascularity is due to soluble VEGF receptor-1
Balamurali K. Ambati,Miho Nozaki,Nirbhai Singh,Atsunobu Takeda,P. Jani,Tushar Suthar,Romulo Albuquerque,Elizabeth Richter,Eiji Sakurai,Eiji Sakurai,Michael T. Newcomb,Mark E. Kleinman,Ruth B. Caldwell,Qing Lin,Yuichiro Ogura,Angela Orecchia,Don Samuelson,Dalen W. Agnew,Dalen W. Agnew,Judy St. Leger,W. Richard Green,Parameshwar J. Mahasreshti,David T. Curiel,Donna Kwan,Helene Marsh,Sakae Ikeda,Lucy J. Leiper,J. Martin Collinson,Sasha Bogdanovich,Tejvir S. Khurana,Masabumi Shibuya,Megan Baldwin,Napoleone Ferrara,Hans-Peter Gerber,Sandro De Falco,Jassir Witta,Judit Z. Baffi,B.J. Raisler,Jayakrishna Ambati +38 more
TL;DR: This paper showed that the cornea expresses soluble VEGF receptor-1 (sVEGFR-1; also known as sflt-1) and that suppression of this endogenous VEGGF-A trap by neutralizing antibodies, RNA interference or Cre-lox-mediated gene disruption abolishes corneal avascularity in mice.
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Vascular endothelial growth factor receptor-1 is deposited in the extracellular matrix by endothelial cells and is a ligand for the alpha 5 beta 1 integrin.
Angela Orecchia,Pedro Miguel Lacal,Cataldo Schietroma,Veronica Morea,Giovanna Zambruno,Cristina Maria Failla +5 more
TL;DR: Results indicate that the soluble VEGFR-1 secreted by endothelial cells becomes a matrix-associated protein that is able to interact with the α5β1 integrin, suggesting a new role of VEGfr-1 in angiogenesis, in addition to growth factor binding.
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Increased Melanoma Growth and Metastasis Spreading in Mice Overexpressing Placenta Growth Factor
Marcella Marcellini,Naomi De Luca,Teresa Riccioni,Alessandro Ciucci,Angela Orecchia,Pedro Miguel Lacal,Federica Ruffini,Maurizio Pesce,Francesca Cianfarani,Giovanna Zambruno,Augusto Orlandi,Cristina Maria Failla +11 more
TL;DR: Transgenic mice overexpressing PlGF in the skin under the control of the keratin 14 promoter indicated that PlGF, in addition to enhancing tumor angiogenesis and favoring tumor growth, may directly influence melanoma dissemination.
Journal ArticleDOI
Evidence for differential S100 gene over-expression in psoriatic patients from genetically heterogeneous pedigrees
Sabrina Semprini,Francesca Capon,Alessandra Tacconelli,Emiliano Giardina,Angela Orecchia,Rita Mingarelli,Tommaso Gobello,Giovanna Zambruno,Annalisa Botta,Giuseppe Fabrizi,Giuseppe Novelli +10 more
TL;DR: Analysis of S100 gene expression in psoriatic individuals from families characterised by linkage studies provides preliminary evidence for a locus-specific molecular mechanism underlying psoriasis susceptibility.
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Monozygotic twins discordant for recessive dystrophic epidermolysis bullosa phenotype highlight the role of TGF-β signalling in modifying disease severity
Teresa Odorisio,Michela Di Salvio,Angela Orecchia,Giovanni Di Zenzo,Eugenia Piccinni,Francesca Cianfarani,Antonella Travaglione,Paolo Uva,Barbara Bellei,Andrea Conti,Giovanna Zambruno,Daniele Castiglia +11 more
TL;DR: The data show that the amount of type VII collagen is not the only determinant of RDEB clinical severity, and indicate an involvement of TGF-β pathways in modulating disease variability, and identify decorin as a possible anti-fibrotic/inflammatory agent for RDEBs therapeutic intervention.