Showing papers by "Angelo C. Pinto published in 2005"
TL;DR: The use of copaiba and sacaca plants as well as their adulteration and side effects, and the new regulations on phytotherapeutic registration in Brazil and Europe are discussed.
Abstract: This paper reviews the recent literature on synergism, adulteration and risks of using medicinal plants. The use of copaiba and sacaca plants as well as their adulteration and side effects, are also described. In addition, the new regulations on phytotherapeutic registration in Brazil and Europe are discussed.
502 citations
TL;DR: Ten indole alkaloids from the chloroform extract of stalk of Tabernaemontana australis were tentatively identified by GC-MS and showed anti-cholinesterasic activity at the same concentration as the reference compounds physostigmine and galanthamine.
114 citations
TL;DR: A series of new amino derivatives and a new partially hydrogenated derivative of the natural naphthoquinone lapachol were assayed for molluscicidal activity against Biomphalaria glabrata and the toxicity is in agreement with the decrease of polar character of the tested compounds.
88 citations
TL;DR: New nitrogen derivatives from norlapachol, including four new diastereomeric 1,2,3,4-tetrahydro-1-aza-anthraquinones obtained from the Prins cyclization on suitable aminoacetaldehyde dimethylacetal derivatives with formic acid, were found to exhibit molluscicidal activity against Biomphalaria glabrata.
54 citations
TL;DR: The data indicate the hypotensive and bradycardia effects of t-DCTN, possibly related in part to the release of nitric oxide and in parts to direct effects on vascular smooth muscle, and cardiac pacemaker activity.
45 citations
TL;DR: The acid fraction of the seeds of C. brasiliensis which contains cyclopentenyl fatty acids is now shown to have significant oral anti-inflammatory and peripheral antinociceptive effects.
Abstract: Carpotroche brasiliensis is a native Brazilian tree belonging to the Oncobeae tribe of Flacourtiaceae. The oil extracted from its seeds contains as major constituents the same cyclopentenyl fatty acids hydnocarpic (40.5%), chaulmoogric (14.0%) and gorlic (16.1%) acids found in the better known chaulmoogra oil prepared from the seeds of various species of Hydnocarpus (Flacourtiaceae). These acids are known to be related to the pharmacological activities of these plants and to their use as anti-leprotic agents. Although C. brasiliensis oil has been used in the treatment of leprosy, a disease that elicits inflammatory responses, the anti-inflammatory and analgesic activities of the oil and its constituents have never been characterized. We describe the anti-inflammatory and antinociceptive activities of C. brasiliensis seed oil in acute and chronic models of inflammation and in peripheral and central nociception. The mixture of acids from C. brasiliensis administered orally by gavage showed dose-dependent (10-500 mg/kg) anti-inflammatory activity in carrageenan-induced rat paw edema, inhibiting both the edema by 30-40% and the associated hyperalgesia. The acid fraction (200 mg/kg) also showed significant antinociceptive activity in acetic acid-induced constrictions (57% inhibition) and formalin-induced pain (55% inhibition of the second phase) in Swiss mice. No effects were observed in the hot-plate (100 mg/kg; N = 10), rota-road (200 mg/kg; N = 9) or adjuvant-induced arthritis (50 mg/kg daily for 7 days; N = 5) tests, the latter a chronic model of inflammation. The acid fraction of the seeds of C. brasiliensis which contains cyclopentenyl fatty acids is now shown to have significant oral anti-inflammatory and peripheral antinociceptive effects.
32 citations
TL;DR: Anti-inflammatory, antinociceptive and anticholinesterasic activities were observed for roots ethanolic extract of C. leprosum and arjunolic acid, suggesting both as promising targets for the development of innovative multi-functional medicines for Alzheimer desease treatment.
Abstract: Combretum leprosum Mart. & Eicher (Combretaceae) leaves and roots ethanolic extracts were investigated by HRGC-MS and showed mono- and oligosaccharides, fatty acids and triterpenes as major compounds after derivatization with BSTFA/ TMCS. Arjunolic acid (1) was quantified on dried roots ethanolic extract (65%) by external standard. Anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities were observed for roots ethanolic extract of C. leprosum and arjunolic acid, suggesting both as promising targets for the development of innovative multi-functional medicines for Alzheimer desease treatment.
32 citations
TL;DR: In this paper, the substances responsible for jujube odour were analyzed by headspace solid-phase microextraction and gas chromatography-mass spectrometry (SPME-GC-MS) associated to standard co-injection and retention indexes, which showed benzaldehyde as major constituent.
Abstract: When in blossom, jujube (Zizyphus mauritiana Lam., Rhamnaceae) emanates a strong fecal odor. The substances responsible for this scent were analysed by headspace solid-phase microextraction and gas chromatography-mass spectrometry (SPME-GC-MS) associated to standard co-injection and retention indexes, which showed benzaldehyde as major constituent. Minor benzenoids, aliphatic carboxylic acids, aldehydes, hydrocarbons and oxygenated monoterpenes were also observed. Olfactometric evaluation of the SPME using GC-sniffing port indicated skatole (3-methyl-indole) as responsible for the fecal odor and vanillin for the sweety odor.
26 citations
TL;DR: In this article it is presented basic information on intellectual property, in special on patent, showed the structure of the patent documents, and it is given notions on International Classification and patent data banks.
Abstract: As technological information is published mainly as a patent, it is fundamental for the country development to know the patent system. In this article it is presented basic information on intellectual property, in special on patent. It is showed the structure of the patent documents, and it is given notions on International Classification and patent data banks.
22 citations
TL;DR: In this paper, the authors present their experience in the Chemistry Institute of the Federal University of Rio de Janeiro to deal with the problem of dropping out of the graduate chemistry courses in Brazil.
Abstract: The problem of the dropping out of the graduate chemistry courses is not new in the Brazilian University. What are the principal factors for this dropping out? Are there rules to measure this dropping out? In this work we present our experience in the Chemistry Institute of the Federal University of Rio de Janeiro to deal with this problem.
17 citations
TL;DR: In this paper, the root and leaves of Z. ekmanii were analyzed by spectroscopic analysis and the structures were established by spectro-chemical analysis, including skimmianine, dictamnine, tembamide, sesamin, lupeol and b-sitosterol.
Abstract: Chemical investigation of Z. ekmanii resulted in the isolation of skimmianine, dictamnine, tembamide, sesamin, lupeol and b-sitosterol. The structures were established by spectroscopic analyses. This is the first report on the phytochemical study of the roots and leaves of Z. ekmanii.
TL;DR: A simple method for the quantification of a linoleic oil additive derivative in diesel has been developed and the recovery of additive and the repeatability of the quantitative results are evaluated.
TL;DR: This work demonstrates the presence of bufotenin in the skin secretion of three arboreal amphibian species of the Osteocephalus genus from the Amazon and the Atlantic rain forests using RP-HPLC, ESI-MS/MS, UV, IR and multidimensional NMR techniques.
TL;DR: Anionic macroporous resin in non-aqueous medium was used with success in this article for separation of the acid fraction of Copaifera multijuga (Copaiba oil), rich in labdanic diterpenes and for the methanolic extract of Croton cajucara (acetyl aleuritoric acid).
Abstract: ION EXCHANGE CHROMATOGRAPHY APPLIED TO THE FRACTIONATION OF THE COPAIBA OIL (Copaifera multijuga) AND SACACA (Croton cajucara) EXTRACTS. Plant extracts are usually complex mixtures which contain several molecules of different sizes with varied functional groups. Such extracts are a challenge to the chemist of natural products. Ion exchange chromatography in non-aqueous medium, used for separation of basic or acidic fractions from plant extracts, is an important unit operation in preparative scale separations. Anionic macroporous resin in non-aqueous medium was used with success in this study for separation of the acid fraction of Copaifera multijuga (Copaiba oil), rich in labdanic diterpenes and for the methanolic extract of Croton cajucara (acetyl aleuritoric acid).
TL;DR: The aerial parts of Ruellia menthoides (Acanthaceae) were submitted to steam distillation from which an intense spicy and camphoraceous aroma was obtained as mentioned in this paper.
Abstract: The aerial parts of Ruellia menthoides (Acanthaceae) were submitted to steam distillation from which an intense spicy and camphoraceous aroma was obtained. Gas chromatography–mass spectrometry analysis associated to co-injection of standards suggested mono and sesquiterpenes as the main compounds. Aroma extract dilution analysis indicated 1,8-cineole and S-(−)-camphor as the most intense compounds of the extract using chiral gas chromatography. Odor threshold for both compounds was determined by gas chromatography–olfactometry. Copyright © 2004 John Wiley & Sons, Ltd.
TL;DR: The authors in this article describe the initial document which was the starting point for the discussion of a new series of papers published in this special issue of Quimica Nova which presents an overview of the Chemistry in our country and the perspectives and needs for the next decade.
Abstract: Over the past years the Brazilian Chemical Society (SBQ) has been working on different projects related to the development of Chemistry in Brazil. After a discussion throughout the country two documents have been published in Quimica Nova: "Mobilizing Axes in Chemistry" and "The Chemist's Education". Here, we describe the initial document which was the starting point for the discussion of a new series of papers published in this special issue of Quimica Nova which presents an overview of the Chemistry in our country and the perspectives and needs for the next decade.
TL;DR: In this article, the authors present and discuss the chemist education profile in Brazil from the points of view of the academy and the industry, and emphasize that the chemistry courses need urgently to face the following challenge: to improve the undergraduate's interdisciplinary approach, management abilities and interpersonal relationships.
Abstract: In this paper, we present and discuss the chemist's education profile in Brazil from the points of view of the academy and the industry. We emphasize that the chemistry courses need urgently to face the following challenge: to improve the undergraduate's interdisciplinary approach, management abilities and interpersonal relationships.
TL;DR: In the structures of (III) and (IV), hydrogen bonds connect the molecules to form chains, but the introduction of a chloro substituent in (IV) has a profound effect on the orientation of the molecules within the chains and the packing of the chains in the structure as a whole.
Abstract: Among the title compounds, viz. the acids C10H8ClF2NO3, (I), and C11H11F2NO3, (II), and the amides C14H14F2N2O2, (III), and C14H13ClF2N2O2, (IV), the change of substituent from Cl in (I) to methyl in (II) has a dramatic effect upon the hydrogen bonding between the molecules, which occur in layers in both cases. In the structures of (III) and (IV), hydrogen bonds connect the molecules to form chains, but the introduction of a chloro substituent in (IV) has a profound effect on the orientation of the molecules within the chains and the packing of the chains in the structure as a whole.