C
Carlos Bloch
Researcher at Empresa Brasileira de Pesquisa Agropecuária
Publications - 108
Citations - 3665
Carlos Bloch is an academic researcher from Empresa Brasileira de Pesquisa Agropecuária. The author has contributed to research in topics: Antimicrobial peptides & Peptide sequence. The author has an hindex of 35, co-authored 107 publications receiving 3282 citations. Previous affiliations of Carlos Bloch include University of Brasília.
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Journal ArticleDOI
Activity of wheat α‐amylase inhibitors towards bruchid α‐amylases and structural explanation of observed specificities
Octavio L. Franco,Daniel J. Rigden,Francislete R. Melo,Carlos Bloch,Carlos P. Silva,Maria F. Grossi de Sá +5 more
TL;DR: Improved structural understanding of the bases for the 0.19 structural family inhibitor specificity reported here may prove useful in the future for the rational design of inhibitors possessing altered inhibition characteristics.
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Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells.
Guilherme D. Brand,Guilherme D. Brand,José Roberto S. A. Leite,José Roberto S. A. Leite,Luciano P. Silva,Luciano P. Silva,Sérgio de Albuquerque,Maura V. Prates,Maura V. Prates,Ricardo Bentes Azevedo,Vanessa Carregaro,João Santana da Silva,Vanuza C.L. Sá,Reuber Albuquerque Brandão,Carlos Bloch +14 more
TL;DR: DS 01 is a 29-residue-long peptide with a molecular mass of 2793 Da showing antibacterial properties against Gram-positive and Gram-negative bacteria in the range of 3-25 microm, suggesting its therapeutic value especially as an anti-T.
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Inhibition of trypsin by cowpea thionin: characterization, molecular modeling, and docking.
Francislete R. Melo,Francislete R. Melo,Daniel J. Rigden,Octavio L. Franco,Octavio L. Franco,Luciane V. Mello,Maria B. Ary,Maria F. Grossi de Sá,Carlos Bloch +8 more
TL;DR: The purification and characterization of a new thionin from cowpea with proteinase inhibitory activity is reported, with favorable interface characteristics comparable with structures of trypsin‐inhibitor complexes determined by X‐ray crystallography.
Journal ArticleDOI
Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus.
José Roberto S. A. Leite,Luciano P. Silva,Maria Izabel S. Rodrigues,Maura V. Prates,Guilherme D. Brand,Bruno M. Lacava,Ricardo Bentes Azevedo,Anamélia Lorenzetti Bocca,Sérgio de Albuquerque,Carlos Bloch +9 more
TL;DR: Six novel peptides called phylloseptins showing anti-bacterial and anti-protozoan activities were isolated from the skin secretion of the Brazilian tree-frogs and Phyllomedusa oreades, and Atomic force microscopy experiments indicated that the bacteriolytic properties of these peptides might be related to their disruptive action on the cell membrane.
Journal ArticleDOI
Identification of a novel storage glycine-rich peptide from guava (Psidium guajava) seeds with activity against Gram-negative bacteria
Patrícia B. Pelegrini,André M. Murad,Luciano P. Silva,Rachel C.P. dos Santos,Fabio T. M. Costa,Paula D. Tagliari,Carlos Bloch,Eliane Ferreira Noronha,Robert N.G. Miller,Octavio L. Franco +9 more
TL;DR: Amino acid sequencing revealed clear identity to the plant glycine-rich protein family, with Pg-AMP1 the first such protein with activity towards Gram-negative bacteria, and shows potential to contribute to development of novel antibiotics from natural sources.