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Anna L. Cogen
Researcher at University of California, San Diego
Publications - 22
Citations - 3756
Anna L. Cogen is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Innate immune system & Antimicrobial. The author has an hindex of 18, co-authored 19 publications receiving 3298 citations. Previous affiliations of Anna L. Cogen include University of London & Veterans Health Administration.
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Journal ArticleDOI
Skin microbiota: a source of disease or defence?
TL;DR: Current data contradict some historical classifications of cutaneous microbiota and suggest that these organisms may protect the host, defining them not as simple symbiotic microbes but rather as mutualistic.
Journal ArticleDOI
Commensal bacteria regulate toll-like receptor 3-dependent inflammation after skin injury
Yuping Lai,Anna Di Nardo,Anna Di Nardo,Teruaki Nakatsuji,Teruaki Nakatsuji,Anke Leichtle,Anke Leichtle,Yan Yang,Anna L. Cogen,Anna L. Cogen,Zi Rong Wu,Lora V. Hooper,Richard R. Schmidt,Sonja von Aulock,Katherine A. Radek,Katherine A. Radek,Chun Ming Huang,Chun Ming Huang,Allen F. Ryan,Allen F. Ryan,Richard L. Gallo,Richard L. Gallo +21 more
TL;DR: It is shown for the first time that the skin epithelium requires TLR3 for normal inflammation after wounding and that the microflora can modulate specific cutaneous inflammatory responses.
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Activation of TLR2 by a Small Molecule Produced by Staphylococcus epidermidis Increases Antimicrobial Defense against Bacterial Skin Infections
Yuping Lai,Yuping Lai,Anna L. Cogen,Katherine A. Radek,Hyun Jeong Park,Hyun Jeong Park,Daniel T. MacLeod,Anke Leichtle,Allen F. Ryan,Anna Di Nardo,Richard L. Gallo +10 more
TL;DR: Findings reveal a potential use for normal commensal bacterium S. epidermidis to activate TLR2 signaling and induce antimicrobial peptide expression, thus enabling the skin to mount an enhanced response to pathogens.
Journal ArticleDOI
Selective antimicrobial action is provided by phenol-soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin.
Anna L. Cogen,Kenshi Yamasaki,Katheryn M. Sanchez,Robert A. Dorschner,Yuping Lai,Daniel T. MacLeod,Justin W. Torpey,Michael Otto,Victor Nizet,Victor Nizet,Judy E. Kim,Richard L. Gallo +11 more
TL;DR: Data suggest that the production of PSMgamma and PSMdelta by S. epidermidis can benefit cutaneous immune defense by selectively inhibiting the survival of skin pathogens while maintaining the normal skin microbiome.
Journal ArticleDOI
Statins Enhance Formation of Phagocyte Extracellular Traps
Ohn A. Chow,Maren von Köckritz-Blickwede,A. Taylor Bright,Mary E. Hensler,Annelies S. Zinkernagel,Anna L. Cogen,Richard L. Gallo,Richard L. Gallo,Marc Monestier,Yanming Wang,Christopher K. Glass,Victor Nizet,Victor Nizet,Victor Nizet +13 more
TL;DR: It is concluded that a drug therapy taken chronically by millions alters the functional behavior of phagocytic cells, which could have ramifications for susceptibility and response to bacterial infections in patients receiving statin therapy.