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Yuping Lai
Researcher at East China Normal University
Publications - 51
Citations - 5338
Yuping Lai is an academic researcher from East China Normal University. The author has contributed to research in topics: Antimicrobial peptides & Psoriasis. The author has an hindex of 28, co-authored 47 publications receiving 4515 citations. Previous affiliations of Yuping Lai include University of California, San Diego & University of California.
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Journal ArticleDOI
AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense
Yuping Lai,Richard L. Gallo +1 more
TL;DR: AMPs are multifunctional molecules that have a central role in infection and inflammation and complement their antimicrobial action and favor resolution of infection and repair of damaged epithelia.
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Commensal bacteria regulate toll-like receptor 3-dependent inflammation after skin injury
Yuping Lai,Anna Di Nardo,Anna Di Nardo,Teruaki Nakatsuji,Teruaki Nakatsuji,Anke Leichtle,Anke Leichtle,Yan Yang,Anna L. Cogen,Anna L. Cogen,Zi Rong Wu,Lora V. Hooper,Richard R. Schmidt,Sonja von Aulock,Katherine A. Radek,Katherine A. Radek,Chun Ming Huang,Chun Ming Huang,Allen F. Ryan,Allen F. Ryan,Richard L. Gallo,Richard L. Gallo +21 more
TL;DR: It is shown for the first time that the skin epithelium requires TLR3 for normal inflammation after wounding and that the microflora can modulate specific cutaneous inflammatory responses.
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Activation of TLR2 by a Small Molecule Produced by Staphylococcus epidermidis Increases Antimicrobial Defense against Bacterial Skin Infections
Yuping Lai,Yuping Lai,Anna L. Cogen,Katherine A. Radek,Hyun Jeong Park,Hyun Jeong Park,Daniel T. MacLeod,Anke Leichtle,Allen F. Ryan,Anna Di Nardo,Richard L. Gallo +10 more
TL;DR: Findings reveal a potential use for normal commensal bacterium S. epidermidis to activate TLR2 signaling and induce antimicrobial peptide expression, thus enabling the skin to mount an enhanced response to pathogens.
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Selective antimicrobial action is provided by phenol-soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin.
Anna L. Cogen,Kenshi Yamasaki,Katheryn M. Sanchez,Robert A. Dorschner,Yuping Lai,Daniel T. MacLeod,Justin W. Torpey,Michael Otto,Victor Nizet,Victor Nizet,Judy E. Kim,Richard L. Gallo +11 more
TL;DR: Data suggest that the production of PSMgamma and PSMdelta by S. epidermidis can benefit cutaneous immune defense by selectively inhibiting the survival of skin pathogens while maintaining the normal skin microbiome.
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The antimicrobial peptide‐sensing system aps of Staphylococcus aureus
TL;DR: It is shown that AMPs induce resistance mechanisms in CA‐MRSA via the aps AMP sensor/regulator system, including the d‐alanylation of teichoic acids and putative AMP transport systems such as the vraFG transporter, for which it is demonstrated a function in AMP resistance.