Anna Russano

TL;DR: Evidence is provided that pollen lipids may be recognized as antigens by human T cells through a CD1-dependent pathway and allergic, but not normal subjects, displayed circulating specific IgE and cutaneous weal and flare reactions to phospholipids.

TL;DR: CD1d-restricted γδ T cells specific for phospholipids can represent a key mucosal regulatory subset for the control of early host reactivity against tree pollens and expand the possibilities in diagnostic and therapeutic interventions.

TL;DR: A substantial percentage of TCRγδ+ but few TCRαβ+ from human duodenal mucosa recognize exogenous phospholipids in a CD1-restricted fashion, which could contribute to mucosal homeostasis, but could also favor the emergence of inflammatory or allergic intestinal diseases.

TL;DR: Montelukast has anti‐inflammatory activity in the treatment of allergic diseases but whether this effect is due only to blocking leukotrienes or also owing to inhibiting proliferation and survival of inflammatory cells, is actually unknown.

TL;DR: T cells from the lungs of untreated persons with asthma express Fas receptor are investigated, showing the persistence of allergen-specific T cells at the mucosal surfaces of atopic persons results from local defective surface expression of Fas receptor and subsequent impairment in active, allergenic-driven cell death.