Xiao-Rong Liu

TL;DR: The studies support a model for KIR haplotype diversity based on six basic gene compositions, and suggest that the centromeric half of the KIR genomic region is comprised of three major combinations, while the telomeric half can assume a short form with either 2DS4 or KIR1D or a long form with multiple combinations of several stimulatory KIR genes.

TL;DR: It is confirmed that NK alloreactivity can occur in HLA-matched HSCT, whereolerance to self is either acquired by the stem cell-derived NK cell after exiting the bone marrow or where tolerance to self can be temporarily overcome.

TL;DR: It is demonstrated that many NK cells with anti–HLA-C2 reactivity are present in HLA-C1 homozygous and heterozygous donors with 2 DS1, and 2DS1 positive clones from HLA/C2 homozygOUS donors are frequently tolerant to HLA,C2.

TL;DR: Findings reveal roles for cell-extrinsic HLA in driving NK cell reactivity upward, and cell-intrinso-HLA in maintaining NK cell education.

TL;DR: A novel in‐vitro system for generation of stable 15Rα/15 complexes that represent a potent adjuvant for augmenting the efficacy of adoptive immunotherapy and could be developed for use in combination immunotherapy approaches.