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Anne F. J. Janssen
Researcher at Wageningen University and Research Centre
Publications - 5
Citations - 160
Anne F. J. Janssen is an academic researcher from Wageningen University and Research Centre. The author has contributed to research in topics: Lamin & Biology. The author has an hindex of 1, co-authored 1 publications receiving 120 citations.
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Journal ArticleDOI
Design and self-assembly of simple coat proteins for artificial viruses
Armando Hernandez-Garcia,Daniela J. Kraft,Anne F. J. Janssen,Paul H. H. Bomans,Nico A. J. M. Sommerdijk,Dominique M. E. Thies-Weesie,Marco E. Favretto,Roland Brock,Frits A. de Wolf,Marc W. T. Werten,Paul van der Schoot,Martien A. Cohen Stuart,Renko de Vries +12 more
TL;DR: A rational design for a self-assembling minimal viral coat protein based on simple polypeptide domains is reported, which features precise control over the cooperativity of its self-assembly with single DNA molecules to finally form rod-shaped virus-like particles.
Journal ArticleDOI
Current Methods and Pipelines for Image-Based Quantitation of Nuclear Shape and Nuclear Envelope Abnormalities
TL;DR: An overview of several nuclear abnormalities, including micronuclei, nuclear envelope invaginations, blebs and ruptures, and current methods used for image-based quantification of these abnormalities are reviewed, and several parameters that can be used to quantify nuclear shape are discussed.
Journal ArticleDOI
The BAF A12T mutation disrupts lamin A/C interaction, impairing robust repair of nuclear envelope ruptures in Nestor–Guillermo progeria syndrome cells
Anne F. J. Janssen,Agathe Marcelot,Sophia Y. Breusegem,Y. Legrand,Sophie Zinn-Justin,Delphine Larrieu +5 more
TL;DR: The disrupted interaction does not prevent repair of NE ruptures but instead generates weak points in the NE that lead to a higher frequency of NE re-rupturing in NGPS cells, which could directly contribute to the premature aging phenotype in patients.
The BAF A12T mutation reduces BAF affinity to lamin A/C, preventing its recruitment to nuclear ruptures in Nestor Guillermo Progeria Syndrome
Anne F. J. Janssen,Agathe Marcelot,Sophia Y. Breusegem,Y. Legrand,Sophie Zinn-Justin,Dorian Larrieu +5 more
TL;DR: It is identified that Overexpression of wild-type BAF in a NGPS context rescues lamin A/C recruitment to sites of nuclear rupture, which could explain why the heterozygous A12T mutation does not cause premature ageing.
Posted ContentDOI
The BAF A12T mutation associated with premature aging impedes lamin A/C recruitment to sites of nuclear rupture, contributing to nuclear envelope fragility
Anne F. J. Janssen,Agathe Marcelot,Sophia Y. Breusegem,Y. Legrand,Sophie Zinn-Justin,Dorian Larrieu +5 more
TL;DR: It is identified that overexpression of wild-type BAF in a NGPS context rescues lamin A/C recruitment to sites of nuclear rupture, which could explain why the heterozygous A12T mutation does not cause premature aging.