Anne Le

TL;DR: It is shown that inhibition of LDHA with FX11 is an achievable and tolerable treatment for LDHA-dependent tumors and oxidative stress and cell death are critical aspects of cancer biology to consider for the therapeutical targeting of cancer energy metabolism.

TL;DR: The metabolic responses of a MYC-inducible human Burkitt lymphoma model P493 cell line to aerobic and hypoxic conditions, and to glucose deprivation, are determined using stable isotope-resolved metabolomics to demonstrate an alternative energy-generating glutaminolysis pathway involving a glucose-independent TCA cycle.

TL;DR: Ectopic MYC expression in cancers could concurrently drive aerobic glycolysis and/or oxidative phosphorylation to provide sufficient energy and anabolic substrates for cell growth and proliferation in the context of the tumor microenvironment.

TL;DR: Using MYC-inducible human Burkitt lymphoma model P493 and PC3 human prostate cancer cells, it is shown that MYC suppressed POX/PRODH expression primarily through up-regulating miR-23b*.

TL;DR: It is reported that loss of one copy of Gls blunted tumor progression in an immune-competent MYC-mediated mouse model of hepatocellular carcinoma and small molecule and genetic inhibition of GLS are supported for targeting the tumor cell-autonomous dependence on GLS for cancer therapy.