L
London L.P.J. Ooi
Researcher at Singapore General Hospital
Publications - 203
Citations - 10597
London L.P.J. Ooi is an academic researcher from Singapore General Hospital. The author has contributed to research in topics: Hepatectomy & Hepatocellular carcinoma. The author has an hindex of 51, co-authored 197 publications receiving 8937 citations. Previous affiliations of London L.P.J. Ooi include National University of Singapore.
Papers
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Journal ArticleDOI
Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma
Apinya Jusakul,Apinya Jusakul,Ioana Cutcutache,Chern Han Yong,Jing Quan Lim,Mi Ni Huang,Nisha Padmanabhan,Vishwa Nellore,Sarinya Kongpetch,Alvin Wei Tian Ng,Ley Moy Ng,Su Pin Choo,Swe Swe Myint,Raynoo Thanan,Sanjanaa Nagarajan,Weng Khong Lim,Cedric Chuan Young Ng,Arnoud Boot,Mo Liu,Choon Kiat Ong,Vikneswari Rajasegaran,Stefanus Lie,Alvin Soon Tiong Lim,Tse Hui Lim,Jing Tan,Jia Liang Loh,John R. McPherson,Narong Khuntikeo,Vajaraphongsa Bhudhisawasdi,Puangrat Yongvanit,Sopit Wongkham,Yasushi Totoki,Hiromi Nakamura,Yasuhito Arai,Satoshi Yamasaki,Pierce K. H. Chow,Alexander Y. F. Chung,London L.P.J. Ooi,Kiat Hon Lim,Simona Dima,Dan G. Duda,Irinel Popescu,Philippe Broët,Sen-Yung Hsieh,Ming-Chin Yu,Aldo Scarpa,Jiaming Lai,Di-Xian Luo,André Lopes Carvalho,André Luiz Vettore,Hyungjin Rhee,Young Nyun Park,Ludmil B. Alexandrov,Raluca Gordân,Steven G. Rozen,Tatsuhiro Shibata,Chawalit Pairojkul,Bin Tean Teh,Patrick Tan +58 more
TL;DR: In this paper, the authors analyzed 489 cholangiocarcinoma (CCA) from 10 countries, combining whole-genome (71 cases), targeted/exome, copy-number, gene expression, and DNA methylation information.
Journal ArticleDOI
Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers
Waraporn Chan-on,Waraporn Chan-on,Maarja-Liisa Nairismagi,Choon Kiat Ong,Weng Khong Lim,Simona Dima,Chawalit Pairojkul,Kiat Hon Lim,John R. McPherson,Ioana Cutcutache,Hong Lee Heng,London L.P.J. Ooi,Alexander Y. F. Chung,Pierce K. H. Chow,Peng Chung Cheow,Ser Yee Lee,Su Pin Choo,Iain Beehuat Tan,Dan G. Duda,Anca Nastase,Swe Swe Myint,Bernice Huimin Wong,Anna Gan,Vikneswari Rajasegaran,Cedric Chuan Young Ng,Sanjanaa Nagarajan,Apinya Jusakul,Shenli Zhang,Priya Vohra,Willie Yu,Dachuan Huang,Paiboon Sithithaworn,Puangrat Yongvanit,Sopit Wongkham,Narong Khuntikeo,Vajaraphongsa Bhudhisawasdi,Irinel Popescu,Steven G. Rozen,Patrick Tan,Patrick Tan,Bin Tean Teh +40 more
TL;DR: Functional studies demonstrated tumor suppressive functions for BAP1 and ARID1A, establishing the role of chromatin modulators in CCA pathogenesis and indicating that different causative etiologies may induce distinct somatic alterations, even within the same tumor type.
Journal ArticleDOI
Microvascular invasion is a better predictor of tumor recurrence and overall survival following surgical resection for hepatocellular carcinoma compared to the Milan criteria.
Kheng-Choon Lim,Pierce K. H. Chow,John Carson Allen,Ghim-Song Chia,Miaoshan Lim,Peng-Chung Cheow,Alexander Y. F. Chung,London L.P.J. Ooi,Say Beng Tan +8 more
TL;DR: Assessment of McVI should aid in patient selection for adjuvant treatments to improve outcomes after SR and show that McVI is a better predictor of tumor recurrence and OS than the Milan criteria after SR for HCC.
Journal ArticleDOI
Management of hepatocellular carcinoma in Asia: consensus statement from the Asian Oncology Summit 2009
Donald Poon,Benjamin O. Anderson,Li-Tzong Chen,Koichi Tanaka,Wan Yee Lau,Eric Van Cutsem,Harjit Singh,Wan Cheng Chow,London L.P.J. Ooi,London L.P.J. Ooi,Pierce K. H. Chow,Pierce K. H. Chow,Maung Win Khin,Wen Hsin Koo +13 more
TL;DR: This consensus statement reviews the available medical evidence for management of HCC in Asia, and gives treatment recommendations that are adapted to resource availability in this diverse region with disparate health-care delivery systems.
Journal ArticleDOI
Profiling MicroRNA Expression in Hepatocellular Carcinoma Reveals MicroRNA-224 Up-regulation and Apoptosis Inhibitor-5 as a MicroRNA-224-specific Target
Yu Wang,Alvin T.C. Lee,Joel Z. I. Ma,Jingbo Wang,Jianwei Ren,Yuchen Yang,Erwin Tantoso,Kuo Bin Li,London L.P.J. Ooi,Patrick Tan,Caroline G.L. Lee +10 more
TL;DR: Findings define a true in vivo target of miR-224 and reaffirm the important role of miRNAs in the dysregulation of cellular processes that may ultimately lead to tumorigenesis.