Annemieke M. Timmermans

TL;DR: Extracellular matrix metalloproteinase inducer levels were higher in therapy-resistant tumors and significantly associated with an earlier tumor progression following first line tamoxifen treatment (hazard ratio, 1.87) and ENPP1, EIF3E, and GNB4 were significant associated with progression-free survival upon tamoxIFen treatment for recurrent disease.

TL;DR: The use of CD146 is introduced to detect EpCAM-negative CTCs, thereby improving CTC detection and combined use of anti-CD146 and anti-EpCAM is likely to improve C TC detection in breast cancer patients.

TL;DR: Examination of genes that modulate migration indicated that SRPK1, encoding the splicing factor kinase SRSF protein kinase 1, is relevant to breast cancer outcomes, as it was highly expressed in basal breast cancer.

TL;DR: The characteristics of infiltrating leukocytes in healthy and malignant breast tissue, the prognostic and predictive values of immune cell subsets across different BC subtypes and the various existing immune evasive mechanisms are reviewed.

TL;DR: The tested cytokeratins provided no substantial benefit, but adding CD49f to CK8/18/19 as a selection marker resulted in improved recovery of normal-like cell lines, likely to further improve CTC detection in breast cancer.