Identification of a Putative Protein Profile Associated with Tamoxifen Therapy Resistance in Breast Cancer
Arzu Umar,Hyuk Kang,Annemieke M. Timmermans,Maxime P. Look,Marion E. Meijer-van Gelder,Michael A. den Bakker,Navdeep Jaitly,John W.M. Martens,Theo M. Luider,John A. Foekens,Ljiljana Paša-Tolić +10 more
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TLDR
Extracellular matrix metalloproteinase inducer levels were higher in therapy-resistant tumors and significantly associated with an earlier tumor progression following first line tamoxifen treatment (hazard ratio, 1.87) and ENPP1, EIF3E, and GNB4 were significant associated with progression-free survival upon tamoxIFen treatment for recurrent disease.About:
This article is published in Molecular & Cellular Proteomics.The article was published on 2009-06-01 and is currently open access. It has received 112 citations till now. The article focuses on the topics: Tamoxifen & Breast cancer.read more
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Translational control in cancer.
TL;DR: Clinical efforts are underway to target specific components of the translation apparatus or unique mRNA translation elements for cancer therapeutics to define a new understanding of the role of mRNA translation and protein synthesis in human cancer.
Journal ArticleDOI
Detection of gene pathways with predictive power for breast cancer prognosis
Shuangge Ma,Michael R. Kosorok +1 more
TL;DR: This work analyzes four breast cancer prognosis studies and identifies 97 pathways with significant predictive power for prognosis, providing a useful alternative to existing pathway analysis methods.
Journal ArticleDOI
Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs
TL;DR: A hydrolysis-resistant bis-phosphothioate analog of 2′3″-cGAMP (2′3′-cGsAsMP) with similar affinity for human STING in vitro and 10 times more potent at inducing IFN-β secretion from human THP1 monocytes is synthesized.
Journal ArticleDOI
Quantitative proteomic analysis of single pancreatic islets
Leonie F. Waanders,Karolina Chwalek,Mara Monetti,Chanchal Kumar,Eckhard Lammert,Matthias Mann +5 more
TL;DR: A high sensitivity chromatographic system that measures nanogram protein mixtures for 8 h with very high resolution and provides an inherent technical replicate for direct proteomic analysis of functionally distinct cellular structures opens up perspectives in physiology and pathology.
Journal ArticleDOI
Plasma Membrane Proteomics and Its Application in Clinical Cancer Biomarker Discovery
TL;DR: Identification of potentially useful proteomics-based biomarkers must be validated in larger, well defined retrospective and prospective clinical studies, and these combined efforts should result in identification of biomarkers that will greatly improve early detection, prognosis, and prediction of treatment response.
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TL;DR: The 10-year and 15-year effects of various systemic adjuvant therapies on breast cancer recurrence and survival are reported and it is found that the cumulative reduction in mortality is more than twice as big at 15 years as at 5 years after diagnosis.
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C. W. Elston,Ian O. Ellis +1 more
TL;DR: The results demonstrate that this method for histological grading provides important prognostic information and, if the grading protocol is followed consistently, reproducible results can be obtained.
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Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer.
Yixin Wang,Jan Klijn,Yi Zhang,Anieta M. Sieuwerts,Maxime P. Look,Fei Yang,Dmitri Talantov,Mieke Timmermans,Marion E. Meijer-van Gelder,Jack X. Yu,Tim Jatkoe,Els M.J.J. Berns,David Atkins,John A. Foekens +13 more
TL;DR: The ability to identify patients who have a favourable prognosis could, after independent confirmation, allow clinicians to avoid adjuvant systemic therapy or to choose less aggressive therapeutic options.
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