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Annette Lee
Researcher at The Feinstein Institute for Medical Research
Publications - 129
Citations - 26974
Annette Lee is an academic researcher from The Feinstein Institute for Medical Research. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 63, co-authored 126 publications receiving 25097 citations. Previous affiliations of Annette Lee include North Shore-LIJ Health System & New York University.
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Journal ArticleDOI
Dense Genotyping of Immune-Related Regions Identifies Loci for Rheumatoid Arthritis Risk and Damage in African Americans.
Maria I. Danila,Vincent A. Laufer,Richard J. Reynolds,Qi Yan,Nianjun Liu,Peter K. Gregersen,Annette Lee,Marlena Kern,Carl D. Langefeld,Donna K. Arnett,S. Louis Bridges +10 more
TL;DR: The dense genotyping of the iChip array and the unique LD structure of African Americans are used to validate known risk loci for RA susceptibility and radiographic severity, and to better characterize the associations of AFF3, ETS1 and IL2RA.
Journal ArticleDOI
Gene-level association analysis of systemic sclerosis: A comparison of African-Americans and White populations.
Olga Y. Gorlova,Yafang Li,Ivan P. Gorlov,Jun Ying,Wei V. Chen,Shervin Assassi,John D. Reveille,Frank C. Arnett,Xiaodong Zhou,Lara Bossini-Castillo,Elena López-Isac,Marialbert Acosta-Herrera,Peter K. Gregersen,Annette Lee,Virginia D. Steen,Barri J. Fessler,Dinesh Khanna,Elena Schiopu,Richard M. Silver,Jerry A. Molitor,Daniel E. Furst,Daniel E. Furst,Daniel E. Furst,Suzanne Kafaja,Robert W. Simms,Robert Lafyatis,Patricia Carreira,Carmen P. Simeon,Ivan Castellví,Emma Beltrán,Norberto Ortego,Christopher I. Amos,Javier Martín,Maureen D. Mayes +33 more
TL;DR: The objective of this study was to analyze genetic susceptibility loci in SSc at the gene level and to determine if the detected associations were shared in African-American and White populations, using data from ImmunoChip and GWAS genotyping studies.
Journal ArticleDOI
Genotyping of immune-related genetic variants identifies TYK2 as a novel associated locus for idiopathic inflammatory myopathies
Meghna Jani,Jonathan Massey,Lucy R. Wedderburn,Jiří Vencovský,Katalin Dankó,Ingrid E. Lundberg,Leonid Padyukov,Albert Selva-O'Callaghan,Trdj Radstake,Hazel Platt,Richard B. Warren,Christopher E.M. Griffiths,Annette Lee,Peter K. Gregersen,Frederick W. Miller,W. E. R. Ollier,Robert G. Cooper,Hector Chinoy,Janine A. Lamb +18 more
TL;DR: This work sought to identify novel genetic risk factors in a large cohort of adult/juvenile patients with DM and polymyositis, by genotyping immune-related single nucleotide polymorphisms (SNPs) not captured through the DM GWAS.
Journal ArticleDOI
Immunochip identifies novel, and replicates known, genetic risk loci for rheumatoid arthritis in black South Africans.
Nimmisha Govind,Ananyo Choudhury,Bridget Hodkinson,Claudia Ickinger,Jacqueline Frost,Annette Lee,Peter K. Gregersen,Richard J. Reynolds,S. Louis Bridges,Scott Hazelhurst,Michèle Ramsay,Michèle Ramsay,Mohammed Tikly +12 more
TL;DR: The effects observed across the HLA region are most likely due to HLA-DRB1, and secondary effects in the extended MHC cannot be detected, and seven non-HLA loci are associated with RA in black South Africans.
Journal ArticleDOI
Challenges and Inconsistencies in Using Lysophosphatidic Acid as a Biomarker for Ovarian Cancer.
Tsukasa Yagi,Muhammad Shoaib,Muhammad Shoaib,Cyrus E. Kuschner,Mitsuaki Nishikimi,Lance B Becker,Lance B Becker,Annette Lee,Annette Lee,Junhwan Kim,Junhwan Kim +10 more
TL;DR: The data suggests that the artificial changes in LPA content may contribute to the discrepancies reported in literature, and any future studies planning to measure plasma LPA should carefully design the study protocol to consider these confounding factors.