Y
Yafang Li
Researcher at Baylor College of Medicine
Publications - 46
Citations - 1797
Yafang Li is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Lung cancer & Genome-wide association study. The author has an hindex of 15, co-authored 40 publications receiving 1309 citations. Previous affiliations of Yafang Li include Dartmouth College & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
James D. McKay,Rayjean J. Hung,Younghun Han,Xuchen Zong,Robert Carreras-Torres,David C. Christiani,Neil E. Caporaso,Mattias Johansson,Xiangjun Xiao,Yafang Li,Jinyoung Byun,Alison M. Dunning,Karen A. Pooley,David C. Qian,Xuemei Ji,Geoffrey Liu,Maria Timofeeva,Stig E. Bojesen,Stig E. Bojesen,Stig E. Bojesen,Xifeng Wu,Loic Le Marchand,Demetrios Albanes,Heike Bickeböller,Melinda C. Aldrich,William S. Bush,Adonina Tardón,Gad Rennert,M. Dawn Teare,John K. Field,Lambertus A. Kiemeney,Philip Lazarus,Aage Haugen,Stephen Lam,Matthew B. Schabath,Angeline S. Andrew,Hongbing Shen,Yun Chul Hong,Jian-Min Yuan,Pier Alberto Bertazzi,Angela Cecilia Pesatori,Yuanqing Ye,Nancy Diao,Li Su,Ruyang Zhang,Yonathan Brhane,Natasha B. Leighl,Jakob S Johansen,Anders Mellemgaard,Walid Saliba,Christopher A. Haiman,Lynne R. Wilkens,Ana Fernández-Somoano,Guillermo Fernández-Tardón,Henricus F. M. van der Heijden,Jin Hee Kim,Juncheng Dai,Zhibin Hu,Michael P.A. Davies,Michael W. Marcus,Hans Brunnström,Jonas Manjer,Olle Melander,David C. Muller,Kim Overvad,Antonia Trichopoulou,Rosario Tumino,Jennifer A. Doherty,Matt P Barnett,Chu Chen,Gary E. Goodman,Angela Cox,Fiona Taylor,Penella J. Woll,Irene Brüske,H-Erich Wichmann,H-Erich Wichmann,Judith Manz,Thomas Muley,Angela Risch,Albert Rosenberger,Kjell Grankvist,Mikael Johansson,Frances A. Shepherd,Ming-Sound Tsao,Susanne M. Arnold,Eric B. Haura,Ciprian Bolca,Ivana Holcatova,Vladimir Janout,Milica Kontic,Jolanta Lissowska,Anush Mukeria,Simona Ognjanovic,Tadeusz M Orlowski,Ghislaine Scelo,Beata Swiatkowska,David Zaridze,Per Bakke,Vidar Skaug,Shanbeh Zienolddiny,Eric J. Duell,Lesley M. Butler,Woon-Puay Koh,Yu-Tang Gao,Richard S. Houlston,John McLaughlin,Victoria L. Stevens,Philippe Joubert,Maxime Lamontagne,David C. Nickle,Ma'en Obeidat,Wim Timens,Bin Zhu,Lei Song,Linda Kachuri,María Soler Artigas,María Soler Artigas,Martin D. Tobin,Martin D. Tobin,Louise V. Wain,Louise V. Wain,Thorunn Rafnar,Thorgeir E. Thorgeirsson,Gunnar W Reginsson,Kari Stefansson,Dana B. Hancock,Laura J. Bierut,Margaret R. Spitz,Nathan C. Gaddis,Sharon M. Lutz,Fangyi Gu,Eric O. Johnson,Ahsan Kamal,Claudio W. Pikielny,Dakai Zhu,Sara Lindstroem,Xia Jiang,Rachel F. Tyndale,Rachel F. Tyndale,Georgia Chenevix-Trench,Jonathan Beesley,Yohan Bossé,Stephen J. Chanock,Paul Brennan,Maria Teresa Landi,Christopher I. Amos +146 more
TL;DR: 18 susceptibility loci achieving genome-wide significance are identified, including 10 new loci linked with lung cancer overall and six loci associated with lung adenocarcinoma, highlighting the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer.
Journal ArticleDOI
The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers.
Christopher I. Amos,Joe Dennis,Zhaoming Wang,Jinyoung Byun,Fredrick R. Schumacher,Simon A. Gayther,Graham Casey,David J. Hunter,Thomas A. Sellers,Stephen B. Gruber,Alison M. Dunning,Kyriaki Michailidou,Laura Fachal,Kimberly F. Doheny,Amanda B. Spurdle,Yafang Li,Xiangjun Xiao,Jane Romm,Elizabeth W. Pugh,Gerhard A. Coetzee,Dennis J. Hazelett,Stig E. Bojesen,Charlisse Caga-Anan,Christopher A. Haiman,Ahsan Kamal,Craig Luccarini,Daniel C. Tessier,Daniel Vincent,Francois Bacot,David Van Den Berg,Stefanie A. Nelson,Stephen Demetriades,David E. Goldgar,Fergus J. Couch,Judith L. Forman,Graham G. Giles,Graham G. Giles,David V. Conti,Heike Bickeböller,Angela Risch,Angela Risch,Melanie Waldenberger,Irene Brüske-Hohlfeld,Belynda Hicks,Hua Ling,Lesley McGuffog,Lesley McGuffog,Andy C. H. Lee,Karoline Kuchenbaecker,Penny Soucy,Judith Manz,Julie M. Cunningham,Katja Butterbach,Zsofia Kote-Jarai,Peter Kraft,Liesel M. FitzGerald,Liesel M. FitzGerald,Sara Lindström,Sara Lindström,Marcia Adams,James McKay,Catherine M. Phelan,Sara Benlloch,Linda E. Kelemen,Paul Brennan,Marjorie J. Riggan,Tracy A. O'Mara,Hongbing Shen,Yongyong Shi,Deborah J. Thompson,Marc T. Goodman,Sune F. Nielsen,Andrew Berchuck,Sylvie Laboissiere,Stephanie L. Schmit,Tameka Shelford,Christopher K. Edlund,Jack A. Taylor,John K. Field,Sue K. Park,Kenneth Offit,Kenneth Offit,Kenneth Offit,Mads Thomassen,Rita K. Schmutzler,Laura Ottini,Rayjean J. Hung,Jonathan Marchini,Ali Amin Al Olama,Ulrike Peters,Rosalind A. Eeles,Michael F. Seldin,Elizabeth M. Gillanders,Daniela Seminara,Antonis C. Antoniou,Paul D.P. Pharoah,Georgia Chenevix-Trench,Stephen J. Chanock,Jacques Simard,Douglas F. Easton +99 more
TL;DR: Results from these analyses will enable researchers to identify new susceptibility loci, perform fine-mapping of new or known loci associated with either single or multiple cancers, assess the degree of overlap in cancer causation and pleiotropic effects of loci that have been identified for disease-specific risk, and jointly model genetic, environmental, and lifestyle-related exposures.
Journal ArticleDOI
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways
Heather J. Cordell,Younghun Han,George F. Mells,Yafang Li,Gideon M. Hirschfield,Casey S. Greene,Gang Xie,Brian D. Juran,Dakai Zhu,David C. Qian,James A B Floyd,James A B Floyd,Katherine I. Morley,Katherine I. Morley,Daniele Prati,Ana Lleo,Daniele Cusi,Daniele Cusi,M. Eric Gershwin,Carl A. Anderson,Konstantinos N. Lazaridis,Pietro Invernizzi,Michael F. Seldin,Richard Sandford,Christopher I. Amos,Katherine A. Siminovitch,Erik M. Schlicht,Craig Lammert,Elizabeth J. Atkinson,Landon L. Chan,Mariza de Andrade,Tobias Balschun,Andrew Mason,Robert P. Myers,Jinyi Zhang,Piotr Milkiewicz,Jia Qu,Joseph A. Odin,Velimir A. Luketic,Bruce R. Bacon,Henry C. Bodenheimer,Valentina Liakina,Catherine Vincent,Cynthia Levy,Peter K. Gregersen,Piero Luigi Almasio,Domenico Alvaro,Pietro Andreone,Angelo Andriulli,Cristina Barlassina,Pier Maria Battezzati,Antonio Benedetti,Francesca Bernuzzi,Ilaria Bianchi,Maria Consiglia Bragazzi,Maurizia Rossana Brunetto,Savino Bruno,Giovanni Casella,Barbara Coco,Agostino Colli,Massimo Colombo,Silvia Colombo,Carmela Cursaro,Lory Saveria Crocè,Andrea Crosignani,Maria Francesca Donato,Gianfranco Elia,Luca Fabris,Carlo Ferrari,Annarosa Floreani,Barbara Foglieni,R. Fontana,Andrea Galli,Roberta Lazzari,Fabio Salvatore Macaluso,Federica Malinverno,Fabio Marra,Marco Marzioni,Alberto Mattalia,Renzo Montanari,Lorenzo Morini,Filomena Morisco,S. Mousa Hani,Luigi Muratori,Paolo Muratori,Grazia Anna Niro,Vincenzo Palmieri,Antonio Picciotto,Mauro Podda,Piero Portincasa,Vincenzo Ronca,Floriano Rosina,Sonia Rossi,Ilaria Sogno,Giancarlo Spinzi,M. Spreafico,Mario Strazzabosco,Mario Strazzabosco,Sonia Tarallo,Mirko Tarocchi,Claudio Tiribelli,Pierluigi Toniutto,Maria Vinci,Massimo Zuin,Chin Lye Ch'ng,Mesbah Rahman,Tom Yapp,Richard Sturgess,Chris Healey,Marek Czajkowski,Anton V J Gunasekera,Pranab Gyawali,Purushothaman Premchand,Kapil Kapur,Richard Marley,Graham R. Foster,Alan Watson,Aruna Dias,Javaid Subhani,Rory Harvey,Roger McCorry,David Ramanaden,Jaber Gasem,Richard Evans,Thiriloganathan Mathialahan,Christopher Shorrock,George Lipscomb,Paul Southern,Jeremy Tibble,David Gorard,Altaf Palegwala,Susan Jones,Marco Carbone,Mohamed Dawwas,Graeme J.M. Alexander,Sunil Dolwani,Martin Prince,Matthew Foxton,David A Elphick,H.C. Mitchison,Ian Gooding,Mazn Karmo,Sushma Saksena,Mike Mendall,Minesh Patel,Roland Ede,Andrew Austin,Joanna Sayer,Lorraine Hankey,Christopher Hovell,N Fisher,M J Carter,M J Carter,Konrad Koss,Andrzej Piotrowicz,Charles Grimley,David E. Neal,Guan Lim,Sass Levi,Aftab Ala,Andrea Broad,Athar Saeed,Gordon Wood,Jonathan C Brown,Mark Wilkinson,Harriet Gordon,John Ramage,Jo Ridpath,Theodore Ngatchu,Bob Grover,Syed Shaukat,Ray Shidrawi,G. Abouda,Faiz Ali,Ian Rees,Imroz Salam,Mark Narain,Ashley Brown,Simon D. Taylor-Robinson,Simon Williams,Leonie Grellier,Paul R. Banim,Debasish Das,Andrew Chilton,Michael A. Heneghan,Howard Curtis,Markus Gess,Ian Drake,M. Aldersley,M. Aldersley,Mervyn H. Davies,Mervyn H. Davies,Rebecca Jones,Rebecca Jones,Alastair McNair,Raj Srirajaskanthan,Maxton Pitcher,Maxton Pitcher,Sambit Sen,George Bird,Adrian Barnardo,Paul Kitchen,Kevin Yoong,Oza Chirag,Nurani Sivaramakrishnan,George MacFaul,David Jones,Amir Shah,Chris D. Evans,Subrata Saha,Katharine Pollock,Peter Bramley,Ashis Mukhopadhya,Andrew G. Fraser,Peter R. Mills,Christopher Shallcross,Stewart Campbell,Andrew Bathgate,Alan Shepherd,John F. Dillon,Simon M. Rushbrook,Robert Przemioslo,Christopher Macdonald,Jane Metcalf,Udi Shmueli,Andrew Davis,Asifabbas Naqvi,Thomas Lee,Dyder Stephen,Dyder Stephen,Jane Collier,Howard Klass,Mary Ninkovic,Matthew E. Cramp,Nicholas Sharer,Richard Aspinall,Patrick Goggin,Deb Ghosh,Andrew C. Douds,Barbara Hoeroldt,Jonathan Booth,Earl J. Williams,Hyder Hussaini,William Stableforth,Reuben Ayres,Douglas Thorburn,Eileen Marshall,Andrew K. Burroughs,Steven Mann,Martin Lombard,Paul G. Richardson,Imran Patanwala,Julia Maltby,Matthew J Brookes,Ray Mathew,Samir Vyas,Saket Singhal,Dermot Gleeson,Sharat Misra,Jeff Butterworth,Keith George,Tim Harding,Andrew Douglass,Simon Panter,Jeremy Shearman,Gary Bray,Graham Butcher,Daniel M. Forton,John McLindon,M. L. Cowan,Gregory Whatley,Aditya Mandal,Hemant Gupta,Pradeep Sanghi,Sanjiv Jain,S.P. Pereira,Geeta Prasad,Gill Watts,Mark Wright,James Neuberger,Fiona H. Gordon,Esther Unitt,Allister Grant,Toby E. S. Delahooke,Andrew D. Higham,Alison M. Brind,Mark Cox,Subramaniam Ramakrishnan,Alistair King,Carole Collins,Simon Whalley,Andy Li,Jocelyn Fraser,Andrew Bell,Voi Shim Wong,Amit Singhal,Ian Gee,Yeng Ang,Rupert Ransford,James Gotto,Charles Millson,Jane Bowles,Caradog Thomas,Melanie Harrison,Roman Galaska,Jennie Kendall,Jessica Whiteman,Caroline Lawlor,Catherine Gray,Keith Elliott,Caroline Mulvaney-Jones,Lucie Hobson,Greta Van Duyvenvoorde,Alison Loftus,Katie Seward,Ruth Penn,Jane Maiden,Rose Damant,Janeane Hails,Rebecca Cloudsdale,Valeria Silvestre,Sue Glenn,Eleanor Dungca,Natalie Wheatley,Helen Doyle,Melanie Kent,Caroline Hamilton,Delyth Braim,Helen Wooldridge,Rachel Abrahams,Alison Paton,Nicola Lancaster,Andrew Gibbins,Karen Hogben,Phillipa Desousa,Phillipa Desousa,Florin Muscariu,Janine Musselwhite,Alexandra McKay,Laiting Tan,Carole Foale,Jacqueline Brighton,Kerry Flahive,Estelle Nambela,Paula Townshend,Christopher B. Ford,Sophie Holder,Caroline Palmer,James Featherstone,Mariam Nasseri,Joy Sadeghian,Bronwen Williams,Carol Thomas,Sally Ann Rolls,Abigail Hynes,Claire Duggan,Sarah Jones,Mary M.E. Crossey,Glynis Stansfield,Carolyn MacNicol,Joy Wilkins,Elva Wilhelmsen,Parizade Raymode,Hye Jeong Lee,Emma Durant,Rebecca Bishop,Rebecca Bishop,Noma Ncube,Sherill Tripoli,Sherill Tripoli,Rebecca Casey,Caroline Cowley,Richard A. Miller,Kathryn Houghton,Samantha Ducker,Fiona Wright,Bridget Bird,Gwen Baxter,Janie Keggans,Maggie Hughes,Emma Grieve,Karin Young,D. Williams,Kate Ocker,Frances Hines,Kirsty G. Martin,Caron Innes,Caron Innes,Talal Valliani,Helen Fairlamb,Sarah Thornthwaite,Anne Eastick,Elizabeth Tanqueray,Jennifer Morrison,Becky Holbrook,Julie Browning,Kirsten Walker,Susan Congreave,Susan Congreave,Juliette Verheyden,Juliette Verheyden,Susan Slininger,Susan Slininger,Lizzie Stafford,Denise O'Donnell,Mark A. Ainsworth,Susan Lord,Linda Kent,Linda March,Christine Dickson,Diane Simpson,Beverley Longhurst,Maria Hayes,Ervin Shpuza,Nikki White,Sarah Besley,Sallyanne Pearson,Alice Wright,L. Jones,Emma Gunter,H. Dewhurst,Anna Fouracres,Liz Farrington,Lyn Graves,Suzie Marriott,Marina Leoni,David Tyrer,Kate Martin,Lola Dali-Kemmery,Victoria Lambourne,Marie Green,Dawn Sirdefield,Kelly Amor,Julie Colley,Bal Shinder,Jayne Jones,Marisa Mills,Mandy Carnahan,Natalie Taylor,Kerenza Boulton,Julie Tregonning,Carly Brown,Gayle Clifford,Emily Archer,Maria Hamilton,Janette Curtis,Tracey Shewan,Susan Walsh,Karen Warner,Kimberley Netherton,McDonald Mupudzi,Bridget Gunson,Jane Gitahi,Denise Gocher,Sally Batham,Hilary Pateman,Senayon Desmennu,Jill Conder,Darren Clement,Susan Gallagher,Jacky Orpe,Puiching Chan,Lynn Currie,Lynn O'Donohoe,Metod Oblak,Lisa Morgan,Marie Quinn,Isobel Amey,Yolanda Baird,Donna Cotterill,Lourdes Cumlat,Louise Winter,Sandra Greer,Katie Spurdle,Joanna Allison,Simon Dyer,Helen Sweeting,Jean Kordula +477 more
TL;DR: This work discovers and validate six previously unknown risk loci for PBC and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine–cytokine pathways, for which relevant therapies exist.
Journal ArticleDOI
Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants
Brian D. Juran,Gideon M. Hirschfield,Pietro Invernizzi,Elizabeth J. Atkinson,Yafang Li,Gang Xie,Roman Kosoy,Michael Ransom,Ye Sun,Ilaria Bianchi,Erik M. Schlicht,Ana Lleo,Catalina Coltescu,Francesca Bernuzzi,Mauro Podda,Craig Lammert,Russell Shigeta,Landon L. Chan,Tobias Balschun,Maurizio Marconi,Daniele Cusi,E. Jenny Heathcote,Andrew Mason,Robert P. Myers,Piotr Milkiewicz,Joseph A. Odin,Velimir A. Luketic,Bruce R. Bacon,Henry C. Bodenheimer,Valentina Liakina,Catherine Vincent,Cynthia Levy,Andre Franke,Peter K. Gregersen,Fabrizio Bossa,M. Eric Gershwin,Mariza deAndrade,Christopher I. Amos,Konstantinos N. Lazaridis,Michael F. Seldin,Katherine A. Siminovitch +40 more
TL;DR: To further characterize the genetic basis of primary biliary cirrhosis (PBC), genotyped patients and unaffected controls using a single nucleotide polymorphism array (Immunochip) enriched for autoimmune disease risk loci and identified a novel disease-associated locus near the TNFSF11 gene at 13q14.
Journal ArticleDOI
A Recurrent Mutation in PARK2 Is Associated with Familial Lung Cancer
Dong Hai Xiong,Yian Wang,Elena Kupert,Claire L. Simpson,Susan M. Pinney,Colette Gaba,Diptasri Mandal,Ann G. Schwartz,Ping Yang,Mariza de Andrade,Claudio W. Pikielny,Jinyoung Byun,Yafang Li,Dwight Stambolian,Margaret R. Spitz,Yanhong Liu,Christopher I. Amos,Joan E. Bailey-Wilson,Marshall W. Anderson,Ming You +19 more
TL;DR: The results provide a rationale for further investigations of this specific mutation and gene for evaluation of the possibility of developing targeted therapies against lung cancer in individuals with PARK2 variants by compensating for the loss-of-function effect caused by the associated variation.