A
Annie Xin
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 11
Citations - 2308
Annie Xin is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Cellular differentiation & Transcription factor. The author has an hindex of 9, co-authored 11 publications receiving 2040 citations. Previous affiliations of Annie Xin include Royal Children's Hospital & University of Melbourne.
Papers
More filters
Journal ArticleDOI
The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells
Erika Cretney,Annie Xin,Annie Xin,Wei Shi,Wei Shi,Martina Minnich,Frederick Masson,Frederick Masson,Maria Miasari,Maria Miasari,Gabrielle T. Belz,Gabrielle T. Belz,Gordon K. Smyth,Gordon K. Smyth,Meinrad Busslinger,Stephen L. Nutt,Stephen L. Nutt,Axel Kallies,Axel Kallies +18 more
TL;DR: A differentiation pathway that leads to the acquisition of Treg cell effector functions and requires both IRF4 and Blimp-1 is defined, which was required for IL-10 production by these cells and for their tissue homeostasis.
Journal ArticleDOI
Blimp-1 Transcription Factor Is Required for the Differentiation of Effector CD8+ T Cells and Memory Responses
TL;DR: It is shown that the transcription factor Blimp-1, a crucial regulator of plasma cell differentiation, was required for CD8(+) T cells to differentiate into functional killer T cells in response to influenza virus.
Journal ArticleDOI
The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells
Ajithkumar Vasanthakumar,Kazuyo Moro,Annie Xin,Yang Liao,Renee Gloury,Shimpei Kawamoto,Sidonia Fagarasan,Lisa A. Mielke,Shoukat Afshar-Sterle,Seth L. Masters,Susumu Nakae,Hirohisa Saito,John M. Wentworth,Peng-Peng Li,Wei Liao,Warren J. Leonard,Gordon K. Smyth,Wei Shi,Stephen L. Nutt,Shigeo Koyasu,Axel Kallies +20 more
TL;DR: It is shown that interleukin 33 (IL-33) signaling through the IL-33 receptor ST2 and myeloid differentiation factor MyD88 is essential for development and maintenance of VAT-Treg cells and sustains their transcriptional signature.
Journal ArticleDOI
The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells
Kevin Man,Maria Miasari,Maria Miasari,Wei Shi,Wei Shi,Annie Xin,Annie Xin,Darren C. Henstridge,Simon Preston,Simon Preston,Marc Pellegrini,Marc Pellegrini,Gabrielle T. Belz,Gabrielle T. Belz,Gordon K. Smyth,Gordon K. Smyth,Mark A. Febbraio,Stephen L. Nutt,Stephen L. Nutt,Axel Kallies,Axel Kallies +20 more
TL;DR: In this paper, the authors found that the transcription factor IRF4 was induced in a manner dependent on affinity for the T cell antigen receptor (TCR) and acted as a dose-dependent regulator of the metabolic function of activated T cells.
Journal Article
The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells (vol 14, pg 1155, 2013)
Kevin Man,Maria Miasari,Wei Shi,Annie Xin,Darren C. Henstridge,Simon P. Preston,Marc Pellegrini,Gabrielle T. Belz,Gordon K. Smyth,Mark A. Febbraio,Stephen L. Nutt,Axel Kallies +11 more
TL;DR: IRF4 is an indispensable molecular 'rheostat' that 'translates' TCR affinity into the appropriate transcriptional programs that link metabolic function with the clonal selection and effector differentiation of T cells.