Ansley S. Conchola

TL;DR: In this paper , using spatial transcriptomics and single-cell profiling of microdissected distal airways, the authors identify molecularly distinct bronchioles (TRBs) cell types that have not-to our knowledge-been previously characterized.

TL;DR: In this article, single cell RNA sequencing data from multiple human lung specimens and identified a mesenchymal cell population present during development that is highly enriched for expression of the WNT agonist R-SPONDIN2 (RSPO2), and adjacent epithelial bud tip progenitors are enriched for the RSPO 2 receptor LGR5.

TL;DR: The use of human tissue and the use ofhuman in vitro model systems that have been leveraged to better understand key regulators of human lung development and that have identified uniquely human features of development are discussed.

TL;DR: iPSC-derived lung bud tip progenitors emerge in organoid culture, can be isolated and expanded, are transcriptionally similar to primary bud tip PROGenitors, and can differentiate into airway or alveolar organoids.

TL;DR: It is concluded that SCGB3A2/SFTPB/CFTR cells act as a progenitor cell contributing to the cellular diversity and heterogeneity in the developing human airway.