A
Antoine Cortot
Researcher at French Institute of Health and Medical Research
Publications - 130
Citations - 16881
Antoine Cortot is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Crohn's disease & Inflammatory bowel disease. The author has an hindex of 46, co-authored 128 publications receiving 15817 citations. Previous affiliations of Antoine Cortot include university of lille.
Papers
More filters
Journal ArticleDOI
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Jean-Pierre Hugot,Mathias Chamaillard,Mathias Chamaillard,Habib Zouali,Suzanne Lesage,Jean-Pierre Cézard,Jacques Belaiche,Sven Almer,Curt Tysk,Colm O'Morain,Miquel A. Gassull,Vibeke Binder,Yigael Finkel,Antoine Cortot,Robert Modigliani,Pierre Laurent-Puig,C. Gower-Rousseau,J. Macry,Jean-Frederic Colombel,Mourad Sahbatou,Gilles Thomas,Gilles Thomas +21 more
TL;DR: It is suggested that the NOD2 gene product confers susceptibility to Crohn's disease by altering the recognition of these components and/or by over-activating NF-kB in monocytes, thus documenting a molecular model for the pathogenic mechanism of Crohn’s disease that can now be further investigated.
Journal ArticleDOI
Epidemiology and Natural History of Inflammatory Bowel Diseases
TL;DR: It has been proposed that only aggressive therapeutic approaches, based on treatment of early recurrent lesions in asymptomatic individuals, have a significant impact on progression of these chronic diseases.
Journal ArticleDOI
Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study
Laurent Beaugerie,Nicole Brousse,Anne Marie Bouvier,Jean-Frederic Colombel,Marc Lémann,Jacques Cosnes,Xavier Hébuterne,Antoine Cortot,Yoram Bouhnik,Jean Pierre Gendre,Tabassome Simon,Marc Maynadié,Olivier Hermine,Jean Faivre,Fabrice Carrat +14 more
TL;DR: Patients receiving thiopurines for inflammatory bowel disease have an increased risk of developing lymphoproliferative disorders, and most cases associated withThiopurine exposure matched the pathological range of post-transplant disease.
Journal ArticleDOI
Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease
Arlette Darfeuille-Michaud,Christel Neut,Nicolas Barnich,E Lederman,Patrick Di Martino,Pierre Desreumaux,Luc Gambiez,B Joly,Antoine Cortot,Jean-Frederic Colombel +9 more
TL;DR: E. coli strains isolated from the ileal mucosa of patients with Crohn's disease adhere to differentiated intestinal cells and may disrupt the intestinal barrier by synthesizing an alpha-hemolysin.
Journal ArticleDOI
Clinical, biological, and endoscopic picture of attacks of Crohn's disease: evolution on prednisolone
Robert Modigliani,Jean-Yves Mary,Jean-François Simon,Antoine Cortot,Soulé Jc,Jean-Pierre Gendre,Emmanuel Rene +6 more
TL;DR: In this paper, a multicenter prospective study of 131 patients with active colorectal or ileocolonic Crohn's disease was conducted, where 28 clinical, biological, and endoscopic items were recorded according to a standardized colonoscopic protocol; a previously validated endoscopic index of severity was calculated.