V
Vibeke Binder
Researcher at University of Copenhagen
Publications - 78
Citations - 16520
Vibeke Binder is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Ulcerative colitis & Inflammatory bowel disease. The author has an hindex of 42, co-authored 78 publications receiving 16029 citations. Previous affiliations of Vibeke Binder include Odense University Hospital & Herlev Hospital.
Papers
More filters
Journal ArticleDOI
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Jean-Pierre Hugot,Mathias Chamaillard,Mathias Chamaillard,Habib Zouali,Suzanne Lesage,Jean-Pierre Cézard,Jacques Belaiche,Sven Almer,Curt Tysk,Colm O'Morain,Miquel A. Gassull,Vibeke Binder,Yigael Finkel,Antoine Cortot,Robert Modigliani,Pierre Laurent-Puig,C. Gower-Rousseau,J. Macry,Jean-Frederic Colombel,Mourad Sahbatou,Gilles Thomas,Gilles Thomas +21 more
TL;DR: It is suggested that the NOD2 gene product confers susceptibility to Crohn's disease by altering the recognition of these components and/or by over-activating NF-kB in monocytes, thus documenting a molecular model for the pathogenic mechanism of Crohn’s disease that can now be further investigated.
Journal ArticleDOI
CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease.
Suzanne Lesage,Habib Zouali,Jean-Pierre Cézard,Jean-Frederic Colombel,Jacques Belaiche,Sven Almer,Curt Tysk,Colm O'Morain,Miquel A. Gassull,Vibeke Binder,Yigael Finkel,Robert Modigliani,Corinne Gower-Rousseau,J. Macry,Françoise Merlin,Mathias Chamaillard,Anne-Sophie Jannot,Gilles Thomas,Jean-Pierre Hugot +18 more
TL;DR: The mutational analyses of CARD15 in 453 patients with CD, including 166 sporadic and 287 familial cases, 159 patients with ulcerative colitis (UC), and 103 healthy control subjects provide tools for a DNA-based test of susceptibility and for genetic counseling in inflammatory bowel disease.
Journal ArticleDOI
Familial Occurrence of Inflammatory Bowel Disease
Marianne Orholm,Pia Munkholm,Ebbe Langholz,Ole Haagen Nielsen,Thorkild I. A. Sørensen,Vibeke Binder +5 more
TL;DR: The 10-fold increase in the familial risk of ulcerative colitis and Crohn's disease strongly suggests that these disorders have a genetic cause.
Journal ArticleDOI
Course of ulcerative colitis: Analysis of changes in disease activity over years
TL;DR: About half of patients with UC will be in remission at any time, although 90% have an intermittent course, and relapses are unpredictable except that disease activity in foregoing years indicates with 70%-80% probability that the disease will continue the following year.
Journal ArticleDOI
Frequency of glucocorticoid resistance and dependency in Crohn's disease.
TL;DR: Localisation of disease, age, sex, sex or clinical symptoms did not significantly correlate with outcome, which can be summarised as prolonged steroid response in 44%, steroid dependency in 36%, and steroid resistant in 20% of the patients.