J
Jacques Cosnes
Researcher at Pierre-and-Marie-Curie University
Publications - 195
Citations - 17018
Jacques Cosnes is an academic researcher from Pierre-and-Marie-Curie University. The author has contributed to research in topics: Inflammatory bowel disease & Crohn's disease. The author has an hindex of 55, co-authored 193 publications receiving 14958 citations. Previous affiliations of Jacques Cosnes include University of Paris.
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Journal ArticleDOI
Epidemiology and Natural History of Inflammatory Bowel Diseases
TL;DR: It has been proposed that only aggressive therapeutic approaches, based on treatment of early recurrent lesions in asymptomatic individuals, have a significant impact on progression of these chronic diseases.
Journal ArticleDOI
Long-term evolution of disease behavior of Crohn's disease.
Jacques Cosnes,Stéphane Cattan,Antoine Blain,Laurent Beaugerie,Franck Carbonnel,Rolland Parc,Jean-Pierre Gendre +6 more
TL;DR: Most patients with CD will eventually one day develop a stricturing or a perforating complication, and initial location determines the type of the complication.
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Low counts of Faecalibacterium prausnitzii in colitis microbiota.
Harry Sokol,Philippe Seksik,Jean-Pierre Furet,Olivier Firmesse,Isabelle Nion-Larmurier,Laurent Beaugerie,Jacques Cosnes,Gérard Corthier,P Marteau,Joël Doré +9 more
TL;DR: The fecal microbiota of patients with IBD differs from that of healthy subjects, and the phylum Firmicutes and particularly the species F. prausnitzii, are underrepresented in A‐IBD patients as well as in IC patients, which could be crucial to gut homeostasis.
Journal ArticleDOI
Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study
Laurent Beaugerie,Nicole Brousse,Anne Marie Bouvier,Jean-Frederic Colombel,Marc Lémann,Jacques Cosnes,Xavier Hébuterne,Antoine Cortot,Yoram Bouhnik,Jean Pierre Gendre,Tabassome Simon,Marc Maynadié,Olivier Hermine,Jean Faivre,Fabrice Carrat +14 more
TL;DR: Patients receiving thiopurines for inflammatory bowel disease have an increased risk of developing lymphoproliferative disorders, and most cases associated withThiopurine exposure matched the pathological range of post-transplant disease.
Journal ArticleDOI
CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands
Bruno Lamas,Mathias L. Richard,Valentin Leducq,Hang-Phuong Pham,Marie-Laure Michel,Grégory Da Costa,Chantal Bridonneau,Sarah Jegou,Thomas W. Hoffmann,Jane M. Natividad,Loic Brot,Soraya Taleb,Soraya Taleb,Aurélie Couturier-Maillard,Isabelle Nion-Larmurier,Fatiha Merabtene,Philippe Seksik,Anne Bourrier,Jacques Cosnes,Bernhard Ryffel,Bernhard Ryffel,Laurent Beaugerie,Jean-Marie Launay,Philippe Langella,Ramnik J. Xavier,Harry Sokol +25 more
TL;DR: In this article, a relationship between the host and the gut microbiota govern intestinal homeostasis is revealed, and the authors reveal that host genes affect the composition and function of the Gut microbiota, altering the production of microbial metabolites and intestinal inflammation.