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Antoine E. Karnoub
Researcher at Harvard University
Publications - 41
Citations - 6934
Antoine E. Karnoub is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Metastasis. The author has an hindex of 23, co-authored 37 publications receiving 6407 citations. Previous affiliations of Antoine E. Karnoub include Massachusetts Institute of Technology & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Auto-inhibition of the Dbl Family Protein Tim by an N-terminal Helical Motif
Marielle E. Yohe,Kent L. Rossman,Olivia S. Gardner,Antoine E. Karnoub,Jason T. Snyder,Svetlana Gershburg,Lee M. Graves,Channing J. Der,John Sondek +8 more
TL;DR: This work shows that the Dbl-family protein, Tim, is auto-inhibited by a short, helical motif immediately N-terminal to its DH domain, which directly occludes the catalytic surface of the DH domain to prevent GTPase activation.
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Lysyl Oxidase Is a Strong Determinant of Tumor Cell Colonization in Bone
Caroline Reynaud,Caroline Reynaud,Laura Ferreras,Laura Ferreras,Paola Di Mauro,Paola Di Mauro,Casina W.S. Kan,Casina W.S. Kan,Martine Croset,Martine Croset,Edith Bonnelye,Edith Bonnelye,Floriane Pez,Clémence Thomas,Géraldine Aimond,Antoine E. Karnoub,Marie Brevet,Philippe Clézardin,Philippe Clézardin +18 more
TL;DR: In this article, the authors investigated whether LOX/HIF1 endows colorectal cancer cells with full competence for aggressive colonization in bone and showed that a high LOX expression in primary tumors from patients with colon cancer was associated with poor clinical outcome, irrespective of HIF-1.
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Pentraxin-3 is a PI3K signaling target that promotes stem cell–like traits in basal-like breast cancers
Clémence Thomas,Whitney S. Henry,Benjamin G. Cuiffo,Anthony Y. Collmann,Elisabetta Marangoni,Vanessa Benhamo,Manoj Bhasin,Cheng Fan,Laetitia Fuhrmann,Albert S. Baldwin,Charles M. Perou,Anne Vincent-Salomon,Alex Toker,Antoine E. Karnoub,Antoine E. Karnoub,Antoine E. Karnoub +15 more
TL;DR: Transcriptomic analysis of activated PIK3CA–expressing BLBC cells identified the gene encoding the humoral pattern recognition molecule pentraxin-3 (PTX3) as a critical target of oncogenic PI3K signaling and shows that PTX3 expression is greater in tumor samples from patients with BLBC and that it is prognostic of poor patient survival.
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The insert region of Rac1 is essential for membrane ruffling but not cellular transformation.
TL;DR: The results show that the insert region of Rac1 serves roles in regulating actin organization and cell growth that are distinct from those of the analogous regions of Cdc42 and RhoA and support its involvement in regulating specific downstream effector interactions.
Journal ArticleDOI
Microenvironmental Regulation of Long Noncoding RNA LINC01133 Promotes Cancer Stem Cell-Like Phenotypic Traits in Triple-Negative Breast Cancers
Zhenbo Tu,Johannes Schmöllerl,Benjamin G. Cuiffo,Antoine E. Karnoub,Antoine E. Karnoub,Antoine E. Karnoub +5 more
TL;DR: It is established that LINC01133 is sufficient, on its own, in promoting phenotypic and growth characteristics of cancer stem cell‐like cells, and that it is a direct mediator of the MSC‐triggered miR‐199a‐FOXP2 pathway in TNBC models.