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Antoine E. Karnoub
Researcher at Harvard University
Publications - 41
Citations - 6934
Antoine E. Karnoub is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Metastasis. The author has an hindex of 23, co-authored 37 publications receiving 6407 citations. Previous affiliations of Antoine E. Karnoub include Massachusetts Institute of Technology & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Critical Role of the Pleckstrin Homology Domain in Dbs Signaling and Growth Regulation
TL;DR: It is suggested that the PH domain of Dbs facilitates two distinct roles in the regulation of DH domain function, one critical for GTPase association and activation in vitro and onecritical for phosphoinositide binding and GTP enzyme interaction in vivo, that together promote Dbs association with membranes.
Journal Article
Vav transformation requires activation of multiple GTPases and regulation of gene expression
TL;DR: It is concluded that full Vav transforming activation is mediated by the activation of multiple small GTPases and their subsequent activation of signaling pathways that regulate changes in gene expression.
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Role of MLK3-mediated Activation of p70 S6 Kinase in Rac1 Transformation
TL;DR: It is found that Rac1 transforming activity could be dissociated from Rac1 activation of p70S6K, and co-expression of wild type, but not kinase-dead, MLK3 significantly inhibited Rac 1 transforming activity.
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Role of the pleckstrin homology domain in intersectin-L Dbl homology domain activation of Cdc42 and signaling.
Wendy M. Pruitt,Antoine E. Karnoub,A.Corinne Rakauskas,Michel Guipponi,Stylianos E. Antonarakis,Alexei Kurakin,Brian K. Kay,John Sondek,David P. Siderovski,Channing J. Der +9 more
TL;DR: Surprisingly, it was found that the PH domain was dispensable for guanine nucleotide exchange activity on Cdc42 in vitro, yet thePH domain enhanced the ability of the DH domain to activate CDC42 signaling in vivo.
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Silencing FOXP2 in breast cancer cells promotes cancer stem cell traits and metastasis
TL;DR: The implications of findings that mesenchymal stem cells induce microRNA-mediated FOXP2 repression in breast cancer cells, thus promoting cancer stem cell (CSC) and metastatic traits, are discussed.