A
Antonio Manzo
Researcher at University of Pavia
Publications - 92
Citations - 3594
Antonio Manzo is an academic researcher from University of Pavia. The author has contributed to research in topics: Rheumatoid arthritis & Arthritis. The author has an hindex of 29, co-authored 78 publications receiving 3016 citations. Previous affiliations of Antonio Manzo include Instituto de Medicina Molecular & Queen Mary University of London.
Papers
More filters
Journal ArticleDOI
Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium
Frances Humby,Michele Bombardieri,Antonio Manzo,Stephen Kelly,Mark Blades,Bruce Kirkham,Jo Spencer,Costantino Pitzalis +7 more
TL;DR: It is demonstrated that FDC+ follicular units invariably express AID and are surrounded by ACPA-producing plasma cells, providing strong evidence that ectopic lymphoid structures in the RA synovium are functional and support autoantibody production.
Journal ArticleDOI
Systematic microanatomical analysis of CXCL13 and CCL21 in situ production and progressive lymphoid organization in rheumatoid synovitis.
Antonio Manzo,Samantha Paoletti,Maresa Carulli,Mark C. Blades,Francesca Barone,G Yanni,Oliver FitzGerald,Barry Bresnihan,Roberto Caporali,Carlomaurizio Montecucco,Mariagrazia Uguccioni,Costantino Pitzalis +11 more
TL;DR: The concept that, under inflammatory conditions, CXCL13 and CCL21 participate in lymphoid tissue microanatomical organization, attempting to recapitulate, in an aberrant lymphoid neogenetic process, their homeostatic and morphogenetic physiologic functions is supported.
Journal ArticleDOI
Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sjögren's syndrome
Francesca Barone,Michele Bombardieri,Antonio Manzo,Mark Blades,Peter Morgan,Stephen Challacombe,Guido Valesini,Costantino Pitzalis +7 more
TL;DR: The acquisition of lymphoid features byinflammatory foci in SS is critically associated with the enlargement of the inflammatory foci and with the expression of CXCL13 and CCL21 within the infiltrate, but is not associated with their expression by epithelial cells.
Journal ArticleDOI
Synovial tissue research: a state-of-the-art review
Carl Orr,Elsa Sousa,David L. Boyle,Maya H Buch,Christopher D. Buckley,Juan D. Cañete,Anca I. Catrina,Anca I. Catrina,Ernest Choy,Paul Emery,Ursula Fearon,Andrew Filer,Danielle M. Gerlag,Danielle M. Gerlag,Frances Humby,John D. Isaacs,Søren Andreas Just,Bernard Lauwerys,Benoit Le Goff,Antonio Manzo,Trudy McGarry,Iain B. McInnes,Aurélie Najm,C. Pitzalis,Arthur G. Pratt,Malcolm D. Smith,Paul P. Tak,Paul P. Tak,Rogier M Thurlings,João Eurico Fonseca,Douglas J. Veale +30 more
TL;DR: These approaches are described and how their use in synovial tissue research has improved the understanding of rheumatoid arthritis and identified candidate biomarkers that could be used in disease diagnosis and stratification, as well as in predicting disease course and treatment response.
Journal ArticleDOI
Efficacy and safety of rituximab treatment in early primary Sjögren's syndrome: a prospective, multi-center, follow-up study
Francesco Carubbi,Paola Cipriani,Alessandra Marrelli,Paola Di Benedetto,Piero Ruscitti,Onorina Berardicurti,Ilenia Pantano,Vasiliki Liakouli,Saverio Alvaro,Alessia Alunno,Antonio Manzo,Francesco Ciccia,Roberto Gerli,Giovanni Triolo,Roberto Giacomelli +14 more
TL;DR: This study demonstrated that RTX treatment results in a faster and more pronounced decrease of ESSDAI and other clinical parameters compared to DMARDs treatment, and showed that RTX is a safe and effective agent to be employed in pSS patients with systemic, extra-glandular involvement.