P
Pål Sætrom
Researcher at Norwegian University of Science and Technology
Publications - 122
Citations - 6500
Pål Sætrom is an academic researcher from Norwegian University of Science and Technology. The author has contributed to research in topics: Gene & Gene expression. The author has an hindex of 39, co-authored 116 publications receiving 5667 citations. Previous affiliations of Pål Sætrom include Beckman Research Institute & City of Hope National Medical Center.
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Journal ArticleDOI
MicroRNA-directed transcriptional gene silencing in mammalian cells.
TL;DR: The results suggest the existence of an epigenetic mechanism of miRNA-directed transcriptional gene silencing (TGS) in mammalian cells.
Journal ArticleDOI
An integrated expression atlas of miRNAs and their promoters in human and mouse.
Derek De Rie,Imad Abugessaisa,Tanvir Alam,Erik Arner,Peter Arner,Haitham Ashoor,Gaby Åström,Magda Babina,Nicolas Bertin,A. Maxwell Burroughs,Ailsa J Carlisle,Carsten O. Daub,Michael Detmar,Ruslan Deviatiiarov,Alexandre Fort,Claudia Gebhard,Dan Goldowitz,Sven Guhl,Thomas J. Ha,Jayson Harshbarger,Akira Hasegawa,Kosuke Hashimoto,Meenhard Herlyn,Peter Heutink,Kelly J Hitchens,Chung-Chau Hon,Edward Huang,Edward Huang,Yuri Ishizu,Chieko Kai,Takeya Kasukawa,Peter S Klinken,Timo Lassmann,Charles-Henri Lecellier,Weon Ju Lee,Marina Lizio,Vsevolod J. Makeev,Vsevolod J. Makeev,Vsevolod J. Makeev,Anthony Mathelier,Yulia A. Medvedeva,Niklas Mejhert,Christopher J. Mungall,Shohei Noma,Mitsuhiro Ohshima,Mariko Okada-Hatakeyama,Helena Persson,Patrizia Rizzu,Filip Roudnicky,Pål Sætrom,Hiroki Sato,Jessica Severin,Jay W. Shin,Rolf Swoboda,Hiroshi Tarui,Hiroo Toyoda,Kristoffer Vitting-Seerup,Louise N. Winteringham,Yoko Yamaguchi,Kayoko Yasuzawa,Misako Yoneda,Noriko Yumoto,Susan Zabierowski,Peter G. Zhang,Christine A. Wells,Christine A. Wells,Kim M. Summers,Kim M. Summers,Hideya Kawaji,Albin Sandelin,Michael Rehli,Yoshihide Hayashizaki,Piero Carninci,Alistair R. R. Forrest,Michiel J. L. de Hoon +74 more
TL;DR: An integrated expression atlas of miRNAs and their promoters by deep-sequencing 492 short RNA libraries, with matching Cap Analysis Gene Expression (CAGE) data, is created, establishing a foundation for detailed analysis of miRNA expression patterns and transcriptional control regions.
Journal ArticleDOI
Distance constraints between microRNA target sites dictate efficacy and cooperativity
TL;DR: Analysis of the distance between seed sites of endogenous miRNAs and transfected small interfering RNAs finds that cooperative targeting of sites with a separation in the optimal range can explain some of the siRNA off-target effects that have been reported in the literature.
Journal ArticleDOI
MicroRNAs in Disease and Potential Therapeutic Applications
TL;DR: This review summarizes miRNA biogenesis and biology, explores the potential roles miRNAs can play in a variety of diseases, and suggests some therapeutic applications for restoring or inhibiting miRNA function.
Journal ArticleDOI
Epigenetics and microRNAs.
TL;DR: MicroRNAs regulate protein-coding genes post transcriptionally in higher eukaryotes and their connections to epigenetics are outlined.