A
Antonius Ratte
Researcher at Heidelberg University
Publications - 13
Citations - 282
Antonius Ratte is an academic researcher from Heidelberg University. The author has contributed to research in topics: Voltage clamp & Atrial action potential. The author has an hindex of 8, co-authored 13 publications receiving 204 citations. Previous affiliations of Antonius Ratte include University Hospital Heidelberg.
Papers
More filters
Journal ArticleDOI
Inverse remodelling of K2P3.1 K+ channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific antiarrhythmic drug therapy.
Constanze Schmidt,Felix Wiedmann,Xiaobo Zhou,Jordi Heijman,Jordi Heijman,Niels Voigt,Niels Voigt,Antonius Ratte,Siegfried Lang,Stefan Kallenberger,Chiara Campana,Alexander Weymann,Raffaele De Simone,Gábor Szabó,Arjang Ruhparwar,Klaus Kallenbach,Matthias Karck,Joachim R. Ehrlich,Joachim R. Ehrlich,István Baczkó,Martin Borggrefe,Ursula Ravens,Dobromir Dobrev,Hugo A. Katus,Dierk Thomas +24 more
TL;DR: In this paper, repolarizing K2P3.1 channels, previously implicated in AF pathophysiology, may contribute to shaping the atrial action potential (AP), forming a specific electrical substrate with LV dysfunction that might represent a target for personalized antiarrhythmic therapy.
Journal ArticleDOI
Ion Channel Dysfunctions in Dilated Cardiomyopathy in Limb-Girdle Muscular Dystrophy
Ibrahim El-Battrawy,Zhihan Zhao,Huan Lan,Xin Li,Gökhan Yücel,Siegfried Lang,Katherine Sattler,Jan-Dierk Schünemann,Wolfram-Hubertus Zimmermann,Lukas Cyganek,Jochen Utikal,Thomas Wieland,Karen Bieback,Ralf Bauer,Antonius Ratte,Regina Pribe-Wolferts,Kleopatra Rapti,Daniel Nowak,Janina Wittig,Dierk Thomas,Patrick Most,Hugo A. Katus,Ursula Ravens,Constanze Schmidt,Martin Borggrefe,Xiaobo Zhou,Oliver Müller,Ibrahim Akin +27 more
TL;DR: It is reported here that human induced pluripotent stem cell (hiPSC)–derived cardiomyocytes from a patient with LGMD2I and DCM associated with recurrent ventricular tachycardia displayed ion channel dysfunction and abnormality of calcium homeostasis.
Journal ArticleDOI
Stretch-activated two-pore-domain (K2P) potassium channels in the heart: Focus on atrial fibrillation and heart failure.
Constanze Schmidt,Felix Wiedmann,Stefan Kallenberger,Antonius Ratte,Jan S. Schulte,Beatrix Scholz,Frank U. Müller,Niels Voigt,Maria-Patapia Zafeiriou,Joachim R. Ehrlich,Ursula Tochtermann,Gábor Veres,Arjang Ruhparwar,Matthias Karck,Hugo A. Katus,Dierk Thomas +15 more
TL;DR: Assessment of expression and remodeling of mechanosensitive K2P channels in atrial fibrillation (AF) and heart failure (HF) patients in comparison to murine models suggested a mechanistic contribution to cardiac arrhythmogenesis.
Journal ArticleDOI
Atrial fibrillation and heart failure-associated remodeling of two-pore-domain potassium (K 2P) channels in murine disease models: focus on TASK-1
Felix Wiedmann,Jan S. Schulte,Bruna Gomes,Maria-Patapia Zafeiriou,Antonius Ratte,Franziska S Rathjens,Edda Fehrmann,Beatrix Scholz,Niels Voigt,Frank U. Müller,Dierk Thomas,Hugo A. Katus,Constanze Schmidt +12 more
TL;DR: Dysregulation of atrial TASK-1 expression in murine AF and HF models suggests a mechanistic contribution to arrhythmogenesis, and two-pore-domain potassium channels share functional similarities.
Journal ArticleDOI
The importance of scientific competencies in German medical curricula - the student perspective
TL;DR: Insight into German medical students’ self-perception in relation to both patient care and biomedical research is provided, and recommendations for potential improvements in scientific training are made.