D
Daniel Nowak
Researcher at Heidelberg University
Publications - 131
Citations - 7512
Daniel Nowak is an academic researcher from Heidelberg University. The author has contributed to research in topics: Gene & Haematopoiesis. The author has an hindex of 25, co-authored 114 publications receiving 6486 citations. Previous affiliations of Daniel Nowak include Goethe University Frankfurt & University of California, Los Angeles.
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Journal ArticleDOI
Frequent pathway mutations of splicing machinery in myelodysplasia
Kenichi Yoshida,Masashi Sanada,Yuichi Shiraishi,Daniel Nowak,Yasunobu Nagata,Ryo Yamamoto,Yusuke Sato,Aiko Sato-Otsubo,Ayana Kon,Masao Nagasaki,George Chalkidis,Yutaka Suzuki,Masashi Shiosaka,Ryoichiro Kawahata,Tomoyuki Yamaguchi,Makoto Otsu,Naoshi Obara,Mamiko Sakata-Yanagimoto,Ken Ishiyama,Hiraku Mori,Florian Nolte,Wolf-Karsten Hofmann,Shuichi Miyawaki,Sumio Sugano,Claudia Haferlach,H. Phillip Koeffler,H. Phillip Koeffler,Lee Yung Shih,Torsten Haferlach,Shigeru Chiba,Hiromitsu Nakauchi,Satoru Miyano,Seishi Ogawa +32 more
TL;DR: The results provide the first evidence indicating that genetic alterations of the major splicing components could be involved in human pathogenesis, also implicating a novel therapeutic possibility for myelodysplasia.
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Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantation
Gero Hütter,Daniel Nowak,Maximilian Mossner,Susanne Ganepola,Kristina Allers,Thomas Schneider,Jörg Hofmann,Claudia Kücherer,Olga Blau,Igor Wolfgang Blau,Wolf K. Hofmann,Eckhard Thiel +11 more
TL;DR: Stem cells from a donor who was homozygous for CCR5 delta32 were transplanted in a patient with acute myeloid leukemia and HIV-1 infection and the patient remained without viral rebound 20 months after transplantation and discontinuation of antiretroviral therapy.
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Human haematopoietic stem cell lineage commitment is a continuous process
Lars Velten,Simon Haas,Simon Raffel,Simon Raffel,Sandra Blaszkiewicz,Saiful Islam,Bianca P. Hennig,Christoph Hirche,Christoph Lutz,Eike C. Buss,Daniel Nowak,Tobias Boch,Wolf-Karsten Hofmann,Anthony D. Ho,Wolfgang Huber,Andreas Trumpp,Marieke A.G. Essers,Lars M. Steinmetz,Lars M. Steinmetz +18 more
TL;DR: Flow cytometric, transcriptomic and functional data at single-cell resolution are integrated to quantitatively map early differentiation of human HSCs towards lineage commitment and provide a basis for the understanding of haematopoietic malignancies.
Journal ArticleDOI
Frequent Pathway Mutations of Splicing Machinery in Myelodysplasia
Kenichi Yoshida,Masashi Sanada,Yuichi Shiraishi,Daniel Nowak,Yasunobu Nagata,Ryo Yamamoto,Yusuke Sato,Aiko Sato-Otsubo,Ayana Kon,Masao Nagasaki,George Chalkidis,Yutaka Suzuki,Makoto Otsu,Naoshi Obara,Mamiko Sakata-Yanagimoto,Ken Ishiyama,Hiraku Mori,Florian Nolte,Wolf-Karsten Hofmann,Shuichi Miyawaki,Sumio Sugano,Claudia Haferlach,H. Phillip Koeffler,Lee-Yung Shih,Torsten Haferlach,Shigeru Chiba,Hiromitsu Nakauchi,Satoru Miyano,Seishi Ogawa +28 more
TL;DR: In this article, the authors performed whole-exome sequencing of 29 cases showing myelodysplasia and identified a total of 268 somatic mutations or 9.2 mutations per sample were identified.
Journal ArticleDOI
Myelodysplastic Cells in Patients Reprogram Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell Niche Disease Unit
Hind Medyouf,Maximilian Mossner,Johann Christoph Jann,Florian Nolte,Simon Raffel,Carl Herrmann,Amelie Lier,Christian Eisen,Verena Nowak,Bettina Zens,Katja Müdder,Corinna Klein,Julia Obländer,Stephanie Fey,Jovita Vogler,Alice Fabarius,Eva Riedl,Henning Roehl,Alexander Kohlmann,Marita Staller,Claudia Haferlach,Nadine Muller,Thilo John,Uwe Platzbecker,Georgia Metzgeroth,Wolf-Karsten Hofmann,Andreas Trumpp,Daniel Nowak +27 more
TL;DR: This patient-derived xenograft model provides functional and molecular evidence that MDS is a complex disease that involves both the hematopoietic and stromal compartments.