Marion H. Brown

TL;DR: In diverse tissues OX2 delivers an inhibitory signal for the macrophage lineage, and outside the brain, disruption of CD200-CD200 receptor interaction precipitated susceptibility to collagen-induced arthritis in mice normally resistant to this disease.

TL;DR: It is concluded that CD147 facilitates proper expression of MCT1 and MCT4 at the cell surface, where they remain tightly bound to each other, and may also be important in determining their activity and location.

TL;DR: The first characterization of human CD200R (hCD200R) is reported and its binding characteristics to hCD200 are defined, and two mCD200 receptor-like family members were shown to pair with the activatory adaptor protein, DAP12, suggesting that these receptors would transmit strong activating signals in contrast to the apparent inhibitory signal delivered by triggering the CD 200R.

TL;DR: The unusual tissue distribution of CD200 indicates where myeloid cells can be restrictively controlled through cell-cell contact.

TL;DR: The finding of an additional ligand for CD48 provides an explanation for distinct functional effects observed on perturbing CD2 and CD48 with mAbs or by genetic manipulation.