Christian Bancher

TL;DR: It is suggested that the accumulation of abnormally phosphorylated tau is one of the earliest cytoskeletal changes in the process of tangle formation and exposure of certain ubiquitin epitopes in the pathological fibers may reflect an unsuccessful attempt of proteolytic degradation.

TL;DR: Analysis of DNA fragmentation in situ found evidence for cell death not only of nerve cells but also of oligodendrocytes and microglia in AD brains, and found nuclear alterations suggestive of apoptosis were rare in degenerating cells.

TL;DR: It was showed that with routine sampling and staining methods, neuropathologic examination alone was not fully adequate for differentiating the disorders and a clinicopathologic diagnostic criteria to improve on the NINDS criteria is proposed.

TL;DR: In this article, the activated form of caspase-3, the central effector enzyme of the apoptotic cascade, was detected in granules of granulovacuolar degeneration.

TL;DR: The pattern of neuronal degeneration associated with neuritic AD pathology in both AD and PD may be an important basis of cognitive decline in both disorders.