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Anwesha Nag
Researcher at Harvard University
Publications - 40
Citations - 2234
Anwesha Nag is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 16, co-authored 34 publications receiving 1476 citations. Previous affiliations of Anwesha Nag include Dartmouth College.
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Journal ArticleDOI
Genetic and transcriptional evolution alters cancer cell line drug response
Uri Ben-David,Benjamin A. Siranosian,Gavin Ha,Gavin Ha,Helen Tang,Yaara Oren,Yaara Oren,Kunihiko Hinohara,Kunihiko Hinohara,Craig A. Strathdee,Joshua M. Dempster,Nicholas J. Lyons,Robert Burns,Anwesha Nag,Guillaume Kugener,Beth A. Cimini,Peter Tsvetkov,Yosef E. Maruvka,Ryan O’Rourke,Ryan O’Rourke,Anthony J. Garrity,Andrew A. Tubelli,Pratiti Bandopadhayay,Pratiti Bandopadhayay,Aviad Tsherniak,Francisca Vazquez,Bang Wong,Chet Birger,Mahmoud Ghandi,Aaron R. Thorner,Joshua A. Bittker,Matthew Meyerson,Matthew Meyerson,Gad Getz,Gad Getz,Rameen Beroukhim,Todd R. Golub +36 more
TL;DR: The extent, origins and consequences of genetic variation within human cell lines are studied, providing a framework for researchers to measure such variation in efforts to support maximally reproducible cancer research.
Journal ArticleDOI
miR319a targeting of TCP4 is critical for petal growth and development in Arabidopsis
TL;DR: Analysis of the expression patterns of the three members of the miR319 gene family indicates that these genes have largely non-overlapping expression patterns suggesting thatThese genes have distinct developmental functions.
Journal ArticleDOI
Unique, dual-indexed sequencing adapters with UMIs effectively eliminate index cross-talk and significantly improve sensitivity of massively parallel sequencing
Laura E. MacConaill,Robert Burns,Anwesha Nag,Haley A. Coleman,Michael K. Slevin,Kristina Giorda,Madelyn Light,Kevin Lai,Mirna Jarosz,Matthew S. McNeill,Matthew D. Ducar,Matthew Meyerson,Aaron R. Thorner +12 more
TL;DR: The results suggest that use of such adapters is critical to reduce false positive rates in assays that aim to identify low allele frequency events, and strongly indicate that dual-matched adapters be implemented for all sensitive MPS applications.
Journal ArticleDOI
Cas9 activates the p53 pathway and selects for p53-inactivating mutations.
Oana M. Enache,Veronica Rendo,Mai Abdusamad,Daniel D. Lam,Desiree Davison,Sangita Pal,Naomi Currimjee,Julian M. Hess,Sasha Pantel,Anwesha Nag,Aaron R. Thorner,John G. Doench,Francisca Vazquez,Rameen Beroukhim,Rameen Beroukhim,Todd R. Golub,Uri Ben-David,Uri Ben-David +17 more
TL;DR: Genetic and transcriptional consequences of Cas9 expression induces DNA damage and activates the p53 pathway, and it can lead to the selection of cells with p53-inactivating mutations, and Cas9 is less active in wild-type TP53 cell lines than in TP53- mutant cell lines.
Journal ArticleDOI
Detection of Mutations in Barrett's Esophagus Before Progression to High-Grade Dysplasia or Adenocarcinoma.
Matthew D. Stachler,Matthew D. Stachler,Nicholas D. Camarda,Christopher Deitrick,Anthony Kim,Agoston T. Agoston,Robert D. Odze,Jason L. Hornick,Anwesha Nag,Aaron R. Thorner,Matthew D. Ducar,Amy Noffsinger,Richard H. Lash,Mark Redston,Scott L. Carter,Jon M. Davison,Adam J. Bass,Adam J. Bass +17 more
TL;DR: In genomic analyses of BE tissues from patients with or without later progression to HGD or EAC, significantly higher numbers of TP53 mutations in BE from customers with subsequent progression are found.