Armen Nersesyan

TL;DR: The results of the HUMN(XL) project identified priorities for validation studies, increased the basic knowledge of the assay, and contributed to the creation of a laboratory network which in perspective may allow the evaluation of disease risk associated with MN frequency.

TL;DR: The results show that exposure of oral mucosa cells to genotoxic carcinogens contained in tobacco smoke does not lead to induction of micronuclei in these cells, and indicates that nuclear anomalies may be misinterpreted as micronsuclei with nonspecific DNA stains and lead to false-positive results in studies with cells of epithelial origin.

TL;DR: An updated and more comprehensive version of the cellular and nuclear scoring criteria used in the buccal micronucleus cytome assay is provided accompanied with a photogallery of the various cell types and nuclear anomalies.

TL;DR: Comparisons with results of earlier studies with lymphocytes and cells from internal organs indicate that epithelial cells are more susceptible to the cytotoxic and DNA-damaging properties of the herbicide and its formulation, indicating that inhalation may cause DNA damage in exposed individuals.

TL;DR: The oxidation of DNA, lipids and proteins associated with the incidence of various diseases and the protection against their oxidative damage may be indicative for beneficial health effects of coffee.