Arsênio Rodrigues Oliveira

TL;DR: New thiazoles were identified that inhibit the epimastigote proliferation and were toxic for trypomastigotes without affecting macrophages viability and being considered a good starting point for the development of new anti-Chagas drug candidates.

TL;DR: It is shown that a novel series of phthalimido-thiazoles-structure-based compounds with potential effects against T. cruzi and lead-like characteristics against Chagas disease induced ultrastructural alterations on morphology, flagellum shortening, chromatin condensation, mitochondria swelling, reservosomes alterations and endoplasmic reticulum dilation.

TL;DR: According to the present study, phthalimido‐thiazole compounds exhibit leishmanicidal activity and could be used to develop novel antileishmaniasis drugs and explore potential molecular targets.

TL;DR: The structural design, synthesis and pharmacological evaluation of N-acylhydrazones derived from phthalimide, which substantially impaired TNF-α secretion, expression and reduced IL-1β production similar to thalidomide or Revlimid are described.

TL;DR: The privileged structure phthalimido-thiazoles act as a molecular framework that has antischistosomal activity and most form the basis to the next pre-clinical tests.