Arti B. Gaur

TL;DR: In this article, the miR-200 miRNA family was found to directly target the mRNA of the E-cadherin transcriptional repressors ZEB1 (TCF8/δEF1) and ZEB2 (SMAD-interacting protein 1 [SIP1]/ZFXH1B).

TL;DR: Evidence that microRNA expression patterns may mark specific biological characteristics of tumors and/or mediate biological activities important for the pathobiology of malignant tumors is provided.

TL;DR: Critical in vivo findings demonstrate an important functional linkage between mir-21 and Pdcd4 and further elucidate the molecular mechanisms by which the known high level of mir- 21 expression in glioblastoma can attribute to tumorigenesis--namely, inhibition of PdCD4 and its tumor-suppressive functions.

TL;DR: The data identify miR-200 as a powerful marker and determining factor of the epithelial phenotype of cancer cells as well as an extraordinary marker for cells that express E-cadherin but lack expression of Vimentin.

TL;DR: During acquisition of resistance to HER2 inhibition, metabolic rewiring of breast cancer cells favors reliance on exogenous FA uptake over de novo FA synthesis, defined as an essential survival mechanism in HER2-positive breast cancer.