A
Aruna Ramachandran
Researcher at Harvard University
Publications - 22
Citations - 2488
Aruna Ramachandran is an academic researcher from Harvard University. The author has contributed to research in topics: Myocyte & Transcription factor. The author has an hindex of 16, co-authored 22 publications receiving 1813 citations. Previous affiliations of Aruna Ramachandran include Centre for DNA Fingerprinting and Diagnostics & Broad Institute.
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Journal ArticleDOI
Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer
Susan Bullman,Susan Bullman,Chandra Sekhar Pedamallu,Chandra Sekhar Pedamallu,Ewa Sicinska,Thomas E. Clancy,Xiaoyang Zhang,Xiaoyang Zhang,Diana Cai,Diana Cai,Donna Neuberg,Katherine H. Huang,Fatima Guevara,Timothy Nelson,Otari Chipashvili,Timothy Hagan,Mark Walker,Aruna Ramachandran,Aruna Ramachandran,Begoña Diosdado,Begoña Diosdado,Garazi Serna,Nuria Mulet,Stefania Landolfi,Santiago Ramón y Cajal,Roberta Fasani,Andrew J. Aguirre,Andrew J. Aguirre,Andrew J. Aguirre,Kimmie Ng,Elena Elez,Shuji Ogino,Shuji Ogino,Josep Tabernero,Charles S. Fuchs,William C. Hahn,William C. Hahn,William C. Hahn,Paolo Nuciforo,Matthew Meyerson,Matthew Meyerson,Matthew Meyerson +41 more
TL;DR: Col colonization of human colorectal cancers with Fusobacterium and its associated microbiome—including Bacteroides, Selenomonas, and Prevotella species—is maintained in distal metastases, demonstrating microbiome stability between paired primary and metastatic tumors.
Journal ArticleDOI
Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas
Joshua D. Campbell,Anton Alexandrov,Jaegil Kim,Jeremiah Wala,Alice H. Berger,Chandra Sekhar Pedamallu,Sachet A. Shukla,Guangwu Guo,Angela N. Brooks,Bradley A. Murray,Marcin Imielinski,Xin Hu,Shiyun Ling,Rehan Akbani,Mara Rosenberg,Carrie Cibulskis,Aruna Ramachandran,Eric A. Collisson,David J. Kwiatkowski,Michael S. Lawrence,John N. Weinstein,Roel G.W. Verhaak,Catherine J. Wu,Peter S. Hammerman,Andrew D. Cherniack,Gad Getz,Maxim N. Artyomov,Robert D. Schreiber,Ramaswamy Govindan,Matthew Meyerson +29 more
TL;DR: Although targeted therapies for lung ADC and SqCC are largely distinct, immunotherapies may aid in treatment for both subtypes.
Journal ArticleDOI
Fluidization and resolidification of the human bladder smooth muscle cell in response to transient stretch.
Cheng Chen,Cheng Chen,Ramaswamy Krishnan,Enhua H. Zhou,Aruna Ramachandran,Dhananjay T. Tambe,Kavitha Rajendran,Rosalyn M. Adam,Linhong Deng,Linhong Deng,Jeffrey J. Fredberg +10 more
TL;DR: In the bladder smooth muscle cell, the fluidization response to transient stretch occurs not through signaling pathways, but rather through release of increased tensile forces that drive acute disassociation of actin.
Journal ArticleDOI
Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor.
Xiaoyang Zhang,Peter S. Choi,Peter S. Choi,Joshua M. Francis,Joshua M. Francis,Galen F. Gao,Joshua D. Campbell,Joshua D. Campbell,Aruna Ramachandran,Aruna Ramachandran,Yoichiro Mitsuishi,Yoichiro Mitsuishi,Gavin Ha,Gavin Ha,Juliann Shih,Francisca Vazquez,Aviad Tsherniak,Alison M. Taylor,Alison M. Taylor,Jin Zhou,Zhong Wu,Ashton C. Berger,Marios Giannakis,Marios Giannakis,William C. Hahn,William C. Hahn,Andrew D. Cherniack,Andrew D. Cherniack,Matthew Meyerson +28 more
TL;DR: The importance of KLF5 activation in human cancers is established, the varied genomic mechanisms underlying this occurrence are delineated, and KLf5 is nominated as a putative target for therapeutic intervention in cancer.
Journal ArticleDOI
Genomic and immune profiling of pre-invasive lung adenocarcinoma.
Haiquan Chen,Jian Carrot-Zhang,Jian Carrot-Zhang,Yue Zhao,Haichuan Hu,Samuel S. Freeman,Samuel S. Freeman,Su Yu,Gavin Ha,Alison M. Taylor,Alison M. Taylor,Ashton C. Berger,Lindsay Westlake,Yuanting Zheng,Jiyang Zhang,Aruna Ramachandran,Aruna Ramachandran,Qiang Zheng,Yunjian Pan,Difan Zheng,Shanbo Zheng,Chao Cheng,Muyu Kuang,Xiaoyan Zhou,Yang Zhang,Hang Li,Ting Ye,Yuan Ma,Zhendong Gao,Xiaoting Tao,Han Han,Jun Shang,Ying Yu,Ding Bao,Yechao Huang,Xiangnan Li,Yawei Zhang,Jiaqing Xiang,Yihua Sun,Yuan Li,Andrew D. Cherniack,Andrew D. Cherniack,Joshua D. Campbell,Leming Shi,Matthew Meyerson,Matthew Meyerson +45 more
TL;DR: Exome and transcriptome sequencing is performed on precursor legions and invasive lung adenocarcinomas, identifying recurrently mutated genes in pre/minimally invasive cases, and arm level alteration events linked to immune infiltration.