A
Ashish Kumar
Researcher at Rajendra Memorial Research Institute of Medical Sciences
Publications - 51
Citations - 889
Ashish Kumar is an academic researcher from Rajendra Memorial Research Institute of Medical Sciences. The author has contributed to research in topics: Leishmania donovani & Computer science. The author has an hindex of 14, co-authored 36 publications receiving 651 citations. Previous affiliations of Ashish Kumar include Indian Council of Medical Research.
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Journal ArticleDOI
Mechanism of Amphotericin B Resistance in Clinical Isolates of Leishmania donovani.
Bidyut Purkait,Ashish Kumar,Nilay Nandi,Abul Hasan Sardar,Sushmita Das,Sudeep Kumar,Krishna Pandey,Vidyananda Ravidas,Manish Kumar,Tripti De,Dharmendra Singh,Pradeep Das +11 more
TL;DR: It can be concluded that altered membrane composition, ATP-binding cassette transporters, and an upregulated thiol metabolic pathway have a role in conferring amphotericin B resistance in clinical isolates of Leishmania donovani.
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Leishmania infection activates host mTOR for its survival by M2 macrophage polarization.
Ajay Kumar,Sushmita Das,Abhishek Mandal,Sudha Verma,Kumar Abhishek,Ashish Kumar,Vinod Kumar,Ayan Kumar Ghosh,Pradeep Das +8 more
TL;DR: It is observed that inhibition of M2 macrophage polarization reduced Leishmania survival inside macrophages, suggesting that mTOR plays a crucial role in regulation of M1 macrophAGE polarization and direct the innate immune homeostasis towards parasite survival inside host.
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Proteome changes associated with Leishmania donovani promastigote adaptation to oxidative and nitrosative stresses.
Abul Hasan Sardar,Sudeep Kumar,Ashish Kumar,Bidyut Purkait,Sushmita Das,Abhik Sen,Manish Kumar,Kislay K. Sinha,Dharmendra Singh,Asif Equbal,Vahab Ali,Pradeep Das +11 more
TL;DR: Major changes were observed in enzymatic machinery of pathways involved in maintaining redox homeostasis, trypanothione metabolism, oxidative phosphorylation, superoxide metabolism, mitochondrial respiration process and other essential metabolic pathways, shed light on how Leishmania promastigotes counter ROS and RNS effects during the initial stage of infection.
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Metabolic reconfiguration of the central glucose metabolism: a crucial strategy of Leishmania donovani for its survival during oxidative stress
Ayan Kumar Ghosh,Abul Hasan Sardar,Abhishek Mandal,Savita Saini,Kumar Abhishek,Ashish Kumar,Bidyut Purkait,Ruby Singh,Sushmita Das,Rupkatha Mukhopadhyay,Syamal Roy,Pradeep Das +11 more
TL;DR: This study illustrates that Leishmania donovani strategizes a metabolic reconfiguration for replenishment of NADPH pool to encounter oxidative challenges.
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Synthesis, characterization, and mechanistic studies of a gold nanoparticle-amphotericin B covalent conjugate with enhanced antileishmanial efficacy and reduced cytotoxicity.
Prakash Kumar,Pushkar Shivam,Saptarshi Mandal,Pragya Prasanna,Saurabh Kumar,Surendra Prasad,Ashish Kumar,Prolay Das,Vahab Ali,Shubhankar K. Singh,Debabrata Mandal +10 more
TL;DR: GNP-based delivery of AmB can be a better, cheaper, and safer alternative than available AmB formulations, and improved antileishmanial efficacy and reduced cytotoxicity.