Ashley Moffett

TL;DR: A single-cell atlas of the maternal–fetal interface reveals the cellular organization of the decidua and placenta, and the interactions that are critical for placentation and reproductive success, and develops a repository of ligand–receptor complexes and a statistical tool to predict the cell–cell communication via these molecular interactions.

TL;DR: In this article, the authors tested the idea that recognition of these molecules by killer immunoglobulin receptors (KIRs) on maternal decidual NK cells is a key factor in the development of preeclampsia.

TL;DR: The traditional way to study the immunology of pregnancy follows the classical transplantation model, which views the fetus as an allograft, but a more recent approach focuses on the unique, local uterine immune response to the implanting placenta.

TL;DR: Recent research has focused on placental-uterine interactions in early pregnancy, and the aim now is to translate these findings into new ways to predict, prevent, and treat pre-eclampsia.

TL;DR: It is demonstrated that trophoblast expresses both paternally and maternally inherited HLA-C surface proteins and that maternal KIR AA frequencies are increased in affected pregnancies only when the fetus has more group 2 Hla-C genes than the mother, raising the possibility that there is a deleterious allogeneic effect stemming from paternal C2.