S
Staffan Holmqvist
Researcher at University of Cambridge
Publications - 19
Citations - 3542
Staffan Holmqvist is an academic researcher from University of Cambridge. The author has contributed to research in topics: Alpha-synuclein & Astrocyte. The author has an hindex of 14, co-authored 19 publications receiving 2172 citations. Previous affiliations of Staffan Holmqvist include International Practical Shooting Confederation & Lund University.
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Journal ArticleDOI
Single-cell reconstruction of the early maternal–fetal interface in humans
Roser Vento-Tormo,Roser Vento-Tormo,Mirjana Efremova,Rachel A. Botting,Margherita Y. Turco,Miquel Vento-Tormo,Kerstin B. Meyer,Jong-Eun Park,Emily Stephenson,Krzysztof Polanski,Angela Goncalves,Angela Goncalves,Lucy Gardner,Staffan Holmqvist,Johan Henriksson,Angela Zou,Andrew M. Sharkey,Ben Millar,Barbara A. Innes,Laura Wood,Anna Wilbrey-Clark,Rebecca Payne,Martin A. Ivarsson,Steve Lisgo,Andrew Filby,David H. Rowitch,Judith N. Bulmer,Gavin J. Wright,Michael J. T. Stubbington,Muzlifah Haniffa,Muzlifah Haniffa,Ashley Moffett,Sarah A. Teichmann,Sarah A. Teichmann,Sarah A. Teichmann +34 more
TL;DR: A single-cell atlas of the maternal–fetal interface reveals the cellular organization of the decidua and placenta, and the interactions that are critical for placentation and reproductive success, and develops a repository of ligand–receptor complexes and a statistical tool to predict the cell–cell communication via these molecular interactions.
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Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats
Staffan Holmqvist,Oldriska Chutna,Luc Bousset,Patrick Aldrin-Kirk,Wen Li,Tomas Björklund,Zhan-You Wang,Laurent Roybon,Ronald Melki,Jia-Yi Li,Jia-Yi Li +10 more
TL;DR: The first experimental evidence that different α-synuclein forms can propagate from the gut to the brain is provided, and that microtubule-associated transport is involved in the translocation of aggregated α- synuclein in neurons is provided.
Journal ArticleDOI
Neuronal vulnerability and multilineage diversity in multiple sclerosis
Lucas Schirmer,Dmitry Velmeshev,Staffan Holmqvist,Max Kaufmann,Sebastian Werneburg,Diane Jung,Stephanie Vistnes,John H. Stockley,Adam Young,Maike Steindel,Brian Tung,Brian Tung,Nitasha Goyal,Nitasha Goyal,Aparna Bhaduri,Simone Mayer,Jan Broder Engler,Omer Ali Bayraktar,Robin J.M. Franklin,Maximilian Haeussler,Richard Reynolds,Dorothy P. Schafer,Manuel A. Friese,Lawrence R. Shiow,Arnold R. Kriegstein,David H. Rowitch,David H. Rowitch +26 more
TL;DR: A map of gene expression in lesions from brains of patients with multiple sclerosis is constructed, revealing distinct lineage- and region-specific transcriptomic changes associated with selective cortical neuron damage and glial activation.
Journal ArticleDOI
Niche stiffness underlies the ageing of central nervous system progenitor cells.
Michael Segel,Björn Neumann,Myfanwy Hill,Isabell P. Weber,Carlo Viscomi,Chao Zhao,Adam Young,Chibeza C. Agley,Amelia J Thompson,Ginez A. Gonzalez,Amar Sharma,Staffan Holmqvist,David H. Rowitch,Kristian Franze,Robin J.M. Franklin,Kevin J. Chalut +15 more
TL;DR: It is shown that tissue stiffness is a crucial regulator of ageing in OPCs, and insights into how the function of adult stem and progenitor cells changes with age are provided.
Journal ArticleDOI
Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map
Omer Ali Bayraktar,Omer Ali Bayraktar,Omer Ali Bayraktar,Theresa Bartels,Staffan Holmqvist,Vitalii Kleshchevnikov,Araks Martirosyan,Damon Polioudakis,Damon Polioudakis,Lucile Ben Haim,Adam Young,Mykhailo Y. Batiuk,Kirti Prakash,Alexander Brown,Kenny Roberts,Mercedes F. Paredes,Riki Kawaguchi,John H. Stockley,Khalida Sabeur,Khalida Sabeur,Sandra Chang,Sandra Chang,Eric J. Huang,Peter J. Hutchinson,Erik M. Ullian,Martin Hemberg,Giovanni Coppola,Matthew Holt,Daniel H. Geschwind,Daniel H. Geschwind,David H. Rowitch,David H. Rowitch +31 more
TL;DR: The present study developed a high-content pipeline, the large-area spatial transcriptomic (LaST) map, which can quantify single-cell gene expression in situ, and reveals astrocyte heterogeneity across layers of the mammalian cerebral cortex.