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Ashok N. Hegde
Researcher at Georgia College & State University
Publications - 49
Citations - 3122
Ashok N. Hegde is an academic researcher from Georgia College & State University. The author has contributed to research in topics: Proteasome & Ubiquitin. The author has an hindex of 25, co-authored 48 publications receiving 2907 citations. Previous affiliations of Ashok N. Hegde include Wake Forest University & Columbia University.
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Journal ArticleDOI
Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia
Ashok N. Hegde,Kaoru Inokuchi,Wanzheng Pei,Andrea Casadio,Mirella Ghirardi,Daniel G. Chain,Kelsey C. Martin,Kelsey C. Martin,Eric R. Kandel,Eric R. Kandel,James H. Schwartz +10 more
TL;DR: Through induction of the hydrolase and the resulting up-regulation of the ubiquitin pathway, learning recruits a regulated form of proteolysis that removes inhibitory constraints on long-term memory storage.
Journal ArticleDOI
RAGE potentiates Aβ-induced perturbation of neuronal function in transgenic mice
Ottavio Arancio,H. Zhang,Xi Chen,Chang Lin,Fabrizio Trinchese,Daniela Puzzo,Shumin Liu,Ashok N. Hegde,Shi Fang Yan,Alan Stern,John S. Luddy,Lih-Fen Lue,Douglas G. Walker,Alex E. Roher,Manuel Buttini,Lennart Mucke,Weiying Li,Ann Marie Schmidt,Mark S. Kindy,Mark S. Kindy,Paul A. Hyslop,David M. Stern,Shirley ShiDu Yan +22 more
TL;DR: It is indicated that RAGE is a cofactor for Aβ‐induced neuronal perturbation in a model of Alzheimer's‐type pathology, and its potential as a therapeutic target to ameliorate cellular dysfunction is suggested.
Journal ArticleDOI
Regulatory subunits of cAMP-dependent protein kinases are degraded after conjugation to ubiquitin: a molecular mechanism underlying long-term synaptic plasticity.
TL;DR: It is suggested that degradation is initiated by cAMP, which causes the holoenzyme to dissociate and, further, that the altered R-to-C ratio in Aplysia sensory neurons is maintained in long-term facilitation by newly synthesized proteins that help target R subunits for accelerated degradation.
Journal ArticleDOI
Mechanisms for generating the autonomous cAMP-dependent protein kinase required for long-term facilitation in Aplysia.
Daniel G. Chain,Andrea Casadio,Samuel Schacher,Ashok N. Hegde,Mireille Valbrun,Naoki Yamamoto,Alfred L. Goldberg,Dusan Bartsch,Eric R. Kandel,James H. Schwartz +9 more
TL;DR: The formation of a persistently active cAMP-dependent protein kinase (PKA) is critical for establishing long-term synaptic facilitation (LTF) in Aplysia and appears to be a key function of proteasomes in LTF.
Journal ArticleDOI
Ubiquitin and the synapse.
Ashok N. Hegde,Aaron DiAntonio +1 more
TL;DR: The myriad ways in which ubiquitin functions to sculpt synapses during development, and to remodel synapses for the acquisition and storage of memory are discussed.